The choice of guide RNA (gRNA) for CRISPR-based gene targeting is an essential step in gene editing applications, but the prediction of gRNA specificity remains challenging. Lack of transparency and focus on point estimates of efficiency disregarding...
Archives of pathology & laboratory medicine
Jan 2, 2022
CONTEXT.—: Large cell transformation (LCT) of indolent B-cell lymphomas, such as follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL), signals a worse prognosis, at which point aggressive chemotherapy is initiated. Although LCT is relative...
International braz j urol : official journal of the Brazilian Society of Urology
Jan 1, 2022
OBJECTIVE: Robotic intracorporeal neobladder reconstruction is a complex procedure in which the approximation of the reservoir to the urethral stump can be a demanding step. The aim of the study is to evaluate the reproducibility of a modified poster...
Ultrasound is one of the most widely utilized imaging tools in clinical practice with the advantages of noninvasive nature and ease of use. However, ultrasound examinations have low reproducibility and considerable heterogeneity due to the variabilit...
Binding free energy estimation of drug candidates to their biomolecular target is one of the best quantitative estimators in computer-aided drug discovery. Accurate binding free energy estimation is still a challengeable task even after decades of re...
For many people, the Internet is their primary source of knowledge in today's modern world. Internet users frequently seek health-related information in order to better understand a health problem, seek guidance, or diagnose symptoms. Unfortunately, ...
PURPOSE: Accurate positioning is essential for radiography, and it is especially important to maintain image reproducibility in follow-up observations. The decision on re-taking radiographs is entrusting to the individual radiological technologist. T...
SIGNIFICANCE: Convolutional neural networks (CNNs) show the potential for automated classification of different cancer lesions. However, their lack of interpretability and explainability makes CNNs less than understandable. Furthermore, CNNs may inco...
Deep learning (DL) is a powerful machine learning technique that has increasingly been used to predict surgical outcomes. However, the large quantity of data required and lack of model interpretability represent substantial barriers to the validity a...
OBJECTIVE: The application of robots in the field of pedicle screw placement has achieved great success. However, decompressive laminectomy, a step that is just as critical as pedicle screw placement, does not have a mature robot-assisted system. To ...
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