AIMC Topic: RNA, Long Noncoding

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DMFLDA: A Deep Learning Framework for Predicting lncRNA-Disease Associations.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2021
A growing amount of evidence suggests that long non-coding RNAs (lncRNAs) play important roles in the regulation of biological processes in many human diseases. However, the number of experimentally verified lncRNA-disease associations is very limite...
Humans Genetic Predisposition to Disease Computational Biology RNA, Long Noncoding Transcriptome Deep Learning Neoplasms
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Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells.

Journal of advanced research Nov 19, 2021
INTRODUCTION: The regenerative capacity of mesenchymal stromal cells or medicinal signaling cells (MSCs) is largely mediated by their secreted small extracellular vesicles (sEVs), and the therapeutic efficacy of sEVs can be enhanced by licensing appr...
Secretory Vesicles Extracellular Vesicles Humans RNA, Long Noncoding Cytokines Mesenchymal Stem Cells
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Multi-Run Concrete Autoencoder to Identify Prognostic lncRNAs for 12 Cancers.

International journal of molecular sciences Nov 3, 2021
BACKGROUND: Long non-coding RNA plays a vital role in changing the expression profiles of various target genes that lead to cancer development. Thus, identifying prognostic lncRNAs related to different cancers might help in developing cancer therapy.
Gene Expression Regulation, Neoplastic RNA, Long Noncoding Neoplasms Deep Learning Algorithms Precision Medicine Humans Survival Rate Neural Networks, Computer Biomarkers, Tumor Prognosis
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LGFC-CNN: Prediction of lncRNA-Protein Interactions by Using Multiple Types of Features through Deep Learning.

Genes Oct 24, 2021
Long noncoding RNA (lncRNA) plays a crucial role in many critical biological processes and participates in complex human diseases through interaction with proteins. Considering that identifying lncRNA-protein interactions through experimental methods...
Humans Neural Networks, Computer Protein Interaction Maps Gene Regulatory Networks Computational Biology Animals Deep Learning Datasets as Topic RNA-Binding Proteins RNA, Long Noncoding
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iLncRNAdis-FB: Identify lncRNA-Disease Associations by Fusing Biological Feature Blocks Through Deep Neural Network.

IEEE/ACM transactions on computational biology and bioinformatics Oct 7, 2021
Identification of lncRNA-disease associations is not only important for exploring the disease mechanism, but will also facilitate the molecular targeting drug discovery. Fusing multiple biological information is able to generate a more comprehensive ...
RNA, Long Noncoding Genetic Predisposition to Disease Computational Biology Humans Neural Networks, Computer Neoplasms Deep Learning Algorithms
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A novel lncRNA-protein interaction prediction method based on deep forest with cascade forest structure.

Scientific reports Sep 23, 2021
Long noncoding RNAs (lncRNAs) regulate many biological processes by interacting with corresponding RNA-binding proteins. The identification of lncRNA-protein Interactions (LPIs) is significantly important to well characterize the biological functions...
Zea mays Datasets as Topic Arabidopsis RNA-Binding Proteins RNA, Long Noncoding Machine Learning Computational Biology Humans
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PRPI-SC: an ensemble deep learning model for predicting plant lncRNA-protein interactions.

BMC bioinformatics Aug 24, 2021
BACKGROUND: Plant long non-coding RNAs (lncRNAs) play vital roles in many biological processes mainly through interactions with RNA-binding protein (RBP). To understand the function of lncRNAs, a fundamental method is to identify which types of prote...
RNA-Binding Proteins RNA, Long Noncoding Computational Biology Neural Networks, Computer Deep Learning
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The Emerging Role of Long Non-Coding RNAs and MicroRNAs in Neurodegenerative Diseases: A Perspective of Machine Learning.

Biomolecules Jul 31, 2021
Neurodegenerative diseases (NDs) are characterized by progressive neuronal dysfunction and death of brain cells population. As the early manifestations of NDs are similar, their symptoms are difficult to distinguish, making the timely detection and d...
RNA, Long Noncoding Nerve Tissue Proteins Internet Neurons Amyotrophic Lateral Sclerosis Databases, Genetic Gene Expression Regulation Computational Biology Parkinson Disease Signal Transduction MicroRNAs Machine Learning Alzheimer Disease Software Humans Information Dissemination
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ILDMSF: Inferring Associations Between Long Non-Coding RNA and Disease Based on Multi-Similarity Fusion.

IEEE/ACM transactions on computational biology and bioinformatics Jun 3, 2021
The dysregulation and mutation of long non-coding RNAs (lncRNAs) have been proved to result in a variety of human diseases. Identifying potential disease-related lncRNAs may benefit disease diagnosis, treatment and prognosis. A number of methods have...
Genetic Predisposition to Disease Humans RNA, Long Noncoding Computational Biology Semantics Support Vector Machine
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PlncRNA-HDeep: plant long noncoding RNA prediction using hybrid deep learning based on two encoding styles.

BMC bioinformatics May 12, 2021
BACKGROUND: Long noncoding RNAs (lncRNAs) play an important role in regulating biological activities and their prediction is significant for exploring biological processes. Long short-term memory (LSTM) and convolutional neural network (CNN) can auto...
Bayes Theorem Machine Learning Computational Biology Deep Learning RNA, Long Noncoding
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