PURPOSE: Sepsis, a life-threatening condition from an uncontrolled immune response to infection, is a leading cause of in-hospital mortality. Early detection is crucial, yet traditional diagnostic methods, like SIRS and SOFA, often fail to identify s...
BACKGROUND: Sepsis is a leading cause of mortality worldwide, characterized by a dysregulated host response to infection. Despite the development of multiple clinical practice guidelines (CPGs) to standardize sepsis management, substantial variabilit...
Clinical and experimental pharmacology & physiology
Jul 1, 2025
Sepsis is a life-threatening disease caused by the dysregulation of the immune response. It is important to identify influential genes modulating the immune response in sepsis. In this study, we used P-NET, a biologically informed explainable artific...
Background: In the field of bibliometrics, although some studies have conducted literature reviews and analyses on sepsis, these studies mainly focus on specific areas or technologies, such as the relationship between the gut microbiome and sepsis, o...
Background: Sepsis-associated acute kidney injury (SA-AKI) is a life-threatening complication with mortality rates exceeding 50%, yet its molecular drivers remain poorly defined. Dysregulated coagulation is increasingly implicated in SA-AKI pathogene...
Background: Age and comorbidity significantly impact the prognosis of septic patients and inform treatment decisions. To provide clinicians with effective tools for identifying high-risk patients, this study assesses the predictive value of the age-a...
IMPORTANCE: Sepsis is a major cause of morbidity and mortality, with early intervention shown to improve outcomes. Predictive modeling and artificial intelligence (AI) can aid in early sepsis recognition, but there remains a gap between algorithm dev...
Computer methods and programs in biomedicine
Jun 1, 2025
OBJECTIVE: Early fluid resuscitation is crucial in the treatment of sepsis, yet the optimal dosage remains debated. This study aims to determine the optimal multi-stage fluid resuscitation dosage for sepsis patients.
BACKGROUND: The development of sepsis in the intensive care unit (ICU) is rapid, the golden rescue time is short, and the effective way to reduce mortality is rapid diagnosis and early warning. Therefore, real-time prediction models play a key role i...
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