AIMC Topic: Tissue Inhibitor of Metalloproteinase-1

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Differential gene expression analysis and machine learning identified structural, TFs, cytokine and glycoproteins, including SOX2, TOP2A, SPP1, COL1A1, and TIMP1 as potential drivers of lung cancer.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Feb 10, 2025
BACKGROUND: Lung cancer is a primary global health concern, responsible for a considerable portion of cancer-related fatalities worldwide. Understanding its molecular complexities is crucial for identifying potential targets for treatment. The goal i...
Machine Learning Biomarkers, Tumor Gene Expression Profiling Humans Gene Expression Regulation, Neoplastic Osteopontin Collagen Type I Tissue Inhibitor of Metalloproteinase-1 Protein Interaction Maps Gene Regulatory Networks Lung Neoplasms DNA Topoisomerases, Type II SOXB1 Transcription Factors Poly-ADP-Ribose Binding Proteins Collagen Type I, alpha 1 Chain
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Establishment of a nomogram model based on immune-related genes using machine learning for aortic dissection diagnosis and immunomodulation assessment.

International journal of medical sciences Jan 21, 2025
The clinical manifestation of aortic dissection (AD) is complex and varied, making early diagnosis crucial for patient survival. This study aimed to identify immune-related markers to establish a nomogram model for AD diagnosis. Three datasets from G...
Serum Amyloid P-Component Chemokine CXCL1 Nomograms Databases, Genetic C-Reactive Protein Aortic Dissection Immunomodulation Tissue Inhibitor of Metalloproteinase-1 Gene Expression Profiling Protein Interaction Maps Gene Regulatory Networks Humans Machine Learning Male
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Predictive Model to Identify the Long Time Survivor in Patients with Glioblastoma: A Cohort Study Integrating Machine Learning Algorithms.

Journal of molecular neuroscience : MN Apr 25, 2024
We aimed to develop and validate a predictive model for identifying long-term survivors (LTS) among glioblastoma (GB) patients, defined as those with an overall survival (OS) of more than 3 years. A total of 293 GB patients from CGGA and 169 from TCG...
Algorithms Male Female Middle Aged Brain Neoplasms Transcriptome Humans Machine Learning Nomograms Glioblastoma Tissue Inhibitor of Metalloproteinase-1 Cancer Survivors
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Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model.

Scientific reports Mar 11, 2024
Metabolic dysfunction-associated steatohepatitis (MASH) is a severe liver disease characterized by lipid accumulation, inflammation and fibrosis. The development of MASH therapies has been hindered by the lack of human translational models and limita...
Artificial Intelligence Biomarkers Fatty Liver Fibroblasts Fibrosis Tissue Inhibitor of Metalloproteinase-1 Humans Collagen Type III
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Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-B Pathway.

BioMed research international Dec 3, 2017
BACKGROUND: Garlic-derived S-allylmercaptocysteine (SAMC) has widely been used in many disease therapies. However, the potential effects and mechanism of SAMC on IL-1-stimulated chondrocytes are unclear.
Chondrocytes Osteoarthritis Matrix Metalloproteinases Transcription Factor RelA Cysteine Garlic Humans Interleukin-1beta Tumor Necrosis Factor-alpha Gene Expression Signal Transduction NF-kappa B Collagen Type II Tissue Inhibitor of Metalloproteinase-1
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Sepsis Important Genes Identification Through Biologically Informed Deep Learning and Transcriptomic Analysis.

Clinical and experimental pharmacology & physiology Jul 1, 2025
Sepsis is a life-threatening disease caused by the dysregulation of the immune response. It is important to identify influential genes modulating the immune response in sepsis. In this study, we used P-NET, a biologically informed explainable artific...
Humans Sepsis Signal Transduction Gene Expression Regulation Tissue Inhibitor of Metalloproteinase-1 Gene Expression Profiling Transcriptome Deep Learning
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Investigating the molecular mechanisms associated with ulcerative colitis through the application of single-cell combined spatial transcriptome sequencing.

Frontiers in immunology Jan 1, 2025
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by dysregulated immune responses, resulting in sustained inflammation and ulceration of the colonic and rectal mucosa. To elucidate the cellular subtypes and gene expr...
Colitis, Ulcerative Tissue Inhibitor of Metalloproteinase-1 Mice Disease Models, Animal Mice, Inbred C57BL Animals Humans Male Female Colon Gene Expression Profiling Transcriptome Single-Cell Analysis
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[Effects of Ethanol Extracts of Phellinus lonicerinus on Hepatic Stellate Cells of Fibrosis Liver in Rats].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials Aug 1, 2015
OBJECTIVE: To study the effects of ethanol extracts of Phellinus lonicerinus on hepatic stellate cells of fibrosis liver in rats.
Tissue Inhibitor of Metalloproteinase-1 Matrix Metalloproteinase 1 Actins Basidiomycota Oxidative Stress Carbon Tetrachloride Antioxidants Rats Biological Products Animals Malondialdehyde Transforming Growth Factor beta1 Hepatic Stellate Cells Superoxide Dismutase Liver Cirrhosis
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