AIMC Topic: Serotonin Plasma Membrane Transport Proteins

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Machine Learning Tool for New Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitors.

Molecules (Basel, Switzerland) Jan 31, 2025
Depression, a serious mood disorder, affects about 5% of the population. Currently, there are two groups of antidepressants that are the first-line treatment for depressive disorder: selective serotonin reuptake inhibitors and serotonin-norepinephrin...
Quantitative Structure-Activity Relationship Antidepressive Agents Machine Learning Serotonin and Noradrenaline Reuptake Inhibitors Selective Serotonin Reuptake Inhibitors Serotonin Plasma Membrane Transport Proteins Humans Norepinephrine Plasma Membrane Transport Proteins
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CNSMolGen: A Bidirectional Recurrent Neural Network-Based Generative Model for De Novo Central Nervous System Drug Design.

Journal of chemical information and modeling May 13, 2024
Central nervous system (CNS) drugs have had a significant impact on treating a wide range of neurodegenerative and psychiatric disorders. In recent years, deep learning-based generative models have shown great potential for accelerating drug discover...
Neural Networks, Computer Central Nervous System Agents Molecular Docking Simulation Drug Design Serotonin Plasma Membrane Transport Proteins Humans
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Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.

Cell Dec 16, 2020
Serotonin plays a central role in cognition and is the target of most pharmaceuticals for psychiatric disorders. Existing drugs have limited efficacy; creation of improved versions will require better understanding of serotonergic circuitry, which ha...
Binding Sites Directed Molecular Evolution Behavior, Animal Amygdala Serotonin Plasma Membrane Transport Proteins Photons Serotonin Sleep HEK293 Cells Linear Models Humans Protein Binding Animals Amino Acid Sequence Mice, Inbred C57BL Kinetics Wakefulness Mice Machine Learning Algorithms Brain
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Functional connectivity correlates of response inhibition impairment in anorexia nervosa.

Psychiatry research. Neuroimaging Dec 2, 2015
Anorexia nervosa (AN) is a disorder characterized by high levels of cognitive control and behavioral perseveration. The present study aims at exploring inhibitory control abilities and their functional connectivity correlates in patients with AN. Inh...
Executive Function Serotonin Plasma Membrane Transport Proteins Case-Control Studies Anorexia Nervosa Body Mass Index Catechol O-Methyltransferase Middle Aged Polymorphism, Genetic Psychomotor Performance Humans Neural Networks, Computer Brain Adult Attention Rest Phenotype Magnetic Resonance Imaging Female
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