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A lesson in implementation: A pre-post study of providers' experience with artificial intelligence-based clinical decision support.

International journal of medical informatics Dec 30, 2019
BACKGROUND: To explore attitudes about artificial intelligence (AI) among staff who utilized AI-based clinical decision support (CDS).
Physicians, Primary Care Decision Support Systems, Clinical Quality Improvement Health Personnel Surveys and Questionnaires Glycemic Index Diabetes Mellitus Primary Health Care Health Plan Implementation Humans Ambulatory Care Facilities Artificial Intelligence Software
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Reinforcement Learning for Bioretrosynthesis.

ACS synthetic biology Dec 30, 2019
Metabolic engineering aims to produce chemicals of interest from living organisms, to advance toward greener chemistry. Despite efforts, the research and development process is still long and costly, and efficient computational design tools are requi...
Software Algorithms Metabolic Networks and Pathways Artificial Intelligence Monte Carlo Method Reinforcement, Psychology Enzymes Metabolic Engineering Models, Biological Markov Chains Synthetic Biology
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More Agility to Semantic Similarities Algorithm Implementations.

International journal of environmental research and public health Dec 30, 2019
Algorithms for measuring semantic similarity between Gene Ontology (GO) terms has become a popular area of research in bioinformatics as it can help to detect functional associations between genes and potential impact to the health and well-being of ...
Algorithms Animals Computational Biology Humans Software Semantics Gene Ontology
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SpliceFinder: ab initio prediction of splice sites using convolutional neural network.

BMC bioinformatics Dec 27, 2019
BACKGROUND: Identifying splice sites is a necessary step to analyze the location and structure of genes. Two dinucleotides, GT and AG, are highly frequent on splice sites, and many other patterns are also on splice sites with important biological fun...
Genome RNA Splicing RNA Splice Sites Computational Biology Neural Networks, Computer Databases, Genetic Algorithms Software Base Sequence Humans Animals
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iProDNA-CapsNet: identifying protein-DNA binding residues using capsule neural networks.

BMC bioinformatics Dec 27, 2019
BACKGROUND: Since protein-DNA interactions are highly essential to diverse biological events, accurately positioning the location of the DNA-binding residues is necessary. This biological issue, however, is currently a challenging task in the age of ...
Humans Neural Networks, Computer Software ROC Curve DNA Position-Specific Scoring Matrices Algorithms Reproducibility of Results Amino Acids DNA-Binding Proteins Amino Acid Sequence
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IILLS: predicting virus-receptor interactions based on similarity and semi-supervised learning.

BMC bioinformatics Dec 27, 2019
BACKGROUND: Viral infectious diseases are the serious threat for human health. The receptor-binding is the first step for the viral infection of hosts. To more effectively treat human viral infectious diseases, the hidden virus-receptor interactions ...
Algorithms Reproducibility of Results ROC Curve Viruses Receptors, Virus Humans Least-Squares Analysis Software Supervised Machine Learning
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DeepMF: deciphering the latent patterns in omics profiles with a deep learning method.

BMC bioinformatics Dec 27, 2019
BACKGROUND: With recent advances in high-throughput technologies, matrix factorization techniques are increasingly being utilized for mapping quantitative omics profiling matrix data into low-dimensional embedding space, in the hope of uncovering ins...
Deep Learning Genomics RNA, Messenger Databases, Genetic MicroRNAs Algorithms Computer Simulation Neoplasms Humans Neural Networks, Computer Software
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JCDB: a comprehensive knowledge base for Jatropha curcas, an emerging model for woody energy plants.

BMC genomics Dec 24, 2019
BACKGROUND: Jatropha curcas is an oil-bearing plant, and has seeds with high oil content (~ 40%). Several advantages, such as easy genetic transformation and short generation duration, have led to the emergence of J. curcas as a model for woody energ...
Knowledge Bases Plant Proteins Protein Interaction Mapping Gene Regulatory Networks Genomics Models, Biological Genes, Plant Jatropha Software Gene Expression Profiling
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An automated 3D modeling pipeline for constructing 3D models of MONOGENEAN HARDPART using machine learning techniques.

BMC bioinformatics Dec 24, 2019
BACKGROUND: Studying structural and functional morphology of small organisms such as monogenean, is difficult due to the lack of visualization in three dimensions. One possible way to resolve this visualization issue is to create digital 3D models wh...
Automation, Laboratory Imaging, Three-Dimensional Machine Learning Software
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High-Throughput Prediction of MHC Class I and II Neoantigens with MHCnuggets.

Cancer immunology research Dec 23, 2019
Computational prediction of binding between neoantigen peptides and major histocompatibility complex (MHC) proteins can be used to predict patient response to cancer immunotherapy. Current neoantigen predictors focus on estimation of MHC binding aff...
Neural Networks, Computer Artificial Intelligence Software Algorithms Humans Predictive Value of Tests Histocompatibility Antigens Class I Data Mining Mutation, Missense Neoplasms Cancer Vaccines Histocompatibility Antigens Class II Protein Binding Antigens, Neoplasm Computational Biology CD8-Positive T-Lymphocytes
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