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Artificial intelligence for sex determination of skeletal remains: Application of a deep learning artificial neural network to human skulls.
Journal of forensic and legal medicine
Jan 4, 2019
A deep learning artificial neural network was adapted to the task of sex determination of skeletal remains. The neural network was trained on images of 900 skulls virtually reconstructed from hospital CT scans. When tested on previously unseen images...
Artificial intelligence-based decision-making for age-related macular degeneration.
Theranostics
Jan 1, 2019
Artificial intelligence (AI) based on convolutional neural networks (CNNs) has a great potential to enhance medical workflow and improve health care quality. Of particular interest is practical implementation of such AI-based software as a cloud-base...
Extracting chemical-protein interactions from literature using sentence structure analysis and feature engineering.
Database : the journal of biological databases and curation
Jan 1, 2019
Information about the interactions between chemical compounds and proteins is indispensable for understanding the regulation of biological processes and the development of therapeutic drugs. Manually extracting such information from biomedical litera...
Combining relation extraction with function detection for BEL statement extraction.
Database : the journal of biological databases and curation
Jan 1, 2019
The BioCreative-V community proposed a challenging task of automatic extraction of causal relation network in Biological Expression Language (BEL) from the biomedical literature. Previous studies on this task largely used models induced from other re...
MITK Phenotyping: An open-source toolchain for image-based personalized medicine with radiomics.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Dec 31, 2018
Radiomics - The extraction of quantitative features from radiologic images - shows increasing potential in contributing to modern personalized medicine approaches. MITK Phenotyping is an openly distributed radiomics framework implementing an exhausti...
Polypharmacology Browser PPB2: Target Prediction Combining Nearest Neighbors with Machine Learning.
Journal of chemical information and modeling
Dec 31, 2018
Here we report PPB2 as a target prediction tool assigning targets to a query molecule based on ChEMBL data. PPB2 computes ligand similarities using molecular fingerprints encoding composition (MQN), molecular shape and pharmacophores (Xfp), and subst...
miRBaseConverter: an R/Bioconductor package for converting and retrieving miRNA name, accession, sequence and family information in different versions of miRBase.
BMC bioinformatics
Dec 31, 2018
BACKGROUND: miRBase is the primary repository for published miRNA sequence and annotation data, and serves as the "go-to" place for miRNA research. However, the definition and annotation of miRNAs have been changed significantly across different vers...
Convolutional neural network based on SMILES representation of compounds for detecting chemical motif.
BMC bioinformatics
Dec 31, 2018
BACKGROUND: Previous studies have suggested deep learning to be a highly effective approach for screening lead compounds for new drugs. Several deep learning models have been developed by addressing the use of various kinds of fingerprints and graph ...
iMEGES: integrated mental-disorder GEnome score by deep neural network for prioritizing the susceptibility genes for mental disorders in personal genomes.
BMC bioinformatics
Dec 28, 2018
BACKGROUND: A range of rare and common genetic variants have been discovered to be potentially associated with mental diseases, but many more have not been uncovered. Powerful integrative methods are needed to systematically prioritize both variants ...
Gene ontology improves template selection in comparative protein docking.
Proteins
Dec 27, 2018
Structural characterization of protein-protein interactions is essential for our ability to study life processes at the molecular level. Computational modeling of protein complexes (protein docking) is important as the source of their structure and a...
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