AIMC Topic: Thyroid Hormones

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Leveraging machine learning in precision medicine to unveil organochlorine pesticides as predictive biomarkers for thyroid dysfunction.

Scientific reports Apr 11, 2025
Exposure to organochlorine pesticides (OCPs) poses significant health risks, including cancer, endocrine dysregulation, neurological disorders, and reproductive disruption. This study investigates the association between OCP exposure and thyroid dist...
Humans Male Middle Aged Machine Learning Pesticides Biomarkers Hydrocarbons, Chlorinated Thyroid Diseases Female Precision Medicine Thyroid Hormones Adult
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Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration.

Nature communications Mar 12, 2025
Predicting and quantifying phenotypic consequences of genetic variants in rare disorders is a major challenge, particularly pertinent for 'actionable' genes such as thyroid hormone transporter MCT8 (encoded by the X-linked SLC16A2 gene), where loss-o...
Male Deep Learning Phenotype Female Loss of Function Mutation Muscular Atrophy Genomics Thyroid Hormones Humans Symporters X-Linked Intellectual Disability Muscle Hypotonia Monocarboxylic Acid Transporters
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Correlation between systemic inflammatory response index and thyroid function: 2009-2012 NHANES results.

Frontiers in endocrinology Jan 22, 2024
AIMS: This study investigates the relationship between the Systemic Inflammatory Response Index (SIRI) and thyroid function.
Hypertension Thyroid Hormones Systemic Inflammatory Response Syndrome Nutrition Surveys Pregnancy Humans Female Middle Aged Adult Thyroid Diseases Male
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Hyperthyroidism treatment by alternative therapies based on cupping and dietary-herbal supplementation: a case report.

Drug metabolism and personalized therapy Aug 12, 2021
OBJECTIVES: Hyperthyroidism is characterized by increasing production of thyroid hormone (TH) and decreasing of thyroid stimulation hormone (TSH) secretion. The treatment of hyperthyroidism includes such as anti-thyroid drugs, radioiodine, and thyroi...
Iodine Radioisotopes Dietary Supplements Urticaria Thyrotropin Humans Complementary Therapies Thyroid Hormones Female Carbimazole Hyperthyroidism
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The Interplay Between Epithelial-Mesenchymal Transition (EMT) and the Thyroid Hormones-αvβ3 Axis in Ovarian Cancer.

Hormones & cancer Dec 19, 2017
Ovarian cancer is a highly metastatic disease. The metastatic potential is enhanced by epithelial to mesenchymal transition (EMT) in which αvβ3 integrin plays a role. Thyroid hormones (L-thyroxine, T4, and 3,5,3'-triiodo-L-thyronine, T3) bind this in...
Integrin alphaVbeta3 Snail Family Transcription Factors Zinc Finger E-box-Binding Homeobox 1 Triiodothyronine beta Catenin Thyroid Hormones Vimentin Humans Female Zonula Occludens-1 Protein Epithelial-Mesenchymal Transition Signal Transduction Thyroxine Ovarian Neoplasms Cadherins Cell Line, Tumor Gene Expression Regulation, Neoplastic
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