AIMC Topic: beta Catenin

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Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations.

Nature communications Feb 21, 2024
We introduce a computational approach for the design of target-specific peptides. Our method integrates a Gated Recurrent Unit-based Variational Autoencoder with Rosetta FlexPepDock for peptide sequence generation and binding affinity assessment. Sub...
Peptides beta Catenin NF-kappa B Molecular Dynamics Simulation Deep Learning Protein Binding
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Platelet-rich plasma inhibits Wnt/β-catenin signaling in rabbit cartilage cells activated by IL-1β.

International immunopharmacology Dec 30, 2017
OBJECTIVE: Platelet-rich plasma (PRP) has been reported to alleviate degenerative pathological damage to joint cartilage. This study aimed to investigate the effect of PRP on Wnt/β-catenin signaling in rabbit chondrocytes.
Rabbits Chondrocytes Osteoarthritis beta Catenin Interleukin-1beta Knee Joint Animals Cell Survival Cells, Cultured Wnt Signaling Pathway Cartilage Oligomeric Matrix Protein Wnt1 Protein Glycogen Synthase Kinase 3 beta Platelet-Rich Plasma Collagen Type II
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The Interplay Between Epithelial-Mesenchymal Transition (EMT) and the Thyroid Hormones-αvβ3 Axis in Ovarian Cancer.

Hormones & cancer Dec 19, 2017
Ovarian cancer is a highly metastatic disease. The metastatic potential is enhanced by epithelial to mesenchymal transition (EMT) in which αvβ3 integrin plays a role. Thyroid hormones (L-thyroxine, T4, and 3,5,3'-triiodo-L-thyronine, T3) bind this in...
Triiodothyronine beta Catenin Thyroid Hormones Vimentin Zinc Finger E-box-Binding Homeobox 1 Integrin alphaVbeta3 Snail Family Transcription Factors Zonula Occludens-1 Protein Epithelial-Mesenchymal Transition Thyroxine Cadherins Humans Signal Transduction Female Ovarian Neoplasms Cell Line, Tumor Gene Expression Regulation, Neoplastic
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Exploring the Mechanisms of Sanguinarine in the Treatment of Osteoporosis by Integrating Network Pharmacology Analysis and Deep Learning Technology.

Current computer-aided drug design Jan 1, 2025
BACKGROUND: Sanguinarine (SAN) has been reported to have antioxidant, antiinflammatory, and antimicrobial activities with potential for the treatment of osteoporosis (OP).
Humans Protein Interaction Maps Osteoporosis Mice Animals Molecular Docking Simulation Deep Learning beta Catenin Caspase 3 Network Pharmacology Benzophenanthridines Isoquinolines
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Effects of Jiazhu decoction in combination with cyclophosphamide on breast cancer in mice.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Oct 1, 2019
OBJECTIVE: To investigate the therapeutic effects of Jiazhu decoction (JZD) in combination with cyclophosphamide (CTX) on the growth of breast cancer in mice and to explore the possible molecular mechanisms of action.
Xenograft Model Antitumor Assays Cyclin D1 Drugs, Chinese Herbal Drug Interactions beta Catenin Mice Antineoplastic Agents Cyclophosphamide Breast Neoplasms RNA, Messenger Cell Line, Tumor Animals Genes, myc Gene Expression Regulation, Neoplastic Cell Proliferation
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