AIMC Topic: beta Catenin

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Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations.

Nature communications Feb 21, 2024
We introduce a computational approach for the design of target-specific peptides. Our method integrates a Gated Recurrent Unit-based Variational Autoencoder with Rosetta FlexPepDock for peptide sequence generation and binding affinity assessment. Sub...
Molecular Dynamics Simulation beta Catenin Protein Binding NF-kappa B Peptides Deep Learning
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Platelet-rich plasma inhibits Wnt/β-catenin signaling in rabbit cartilage cells activated by IL-1β.

International immunopharmacology Dec 30, 2017
OBJECTIVE: Platelet-rich plasma (PRP) has been reported to alleviate degenerative pathological damage to joint cartilage. This study aimed to investigate the effect of PRP on Wnt/β-catenin signaling in rabbit chondrocytes.
Platelet-Rich Plasma Collagen Type II Glycogen Synthase Kinase 3 beta Chondrocytes Wnt Signaling Pathway Osteoarthritis Cartilage Oligomeric Matrix Protein beta Catenin Knee Joint Wnt1 Protein Animals Rabbits Cells, Cultured Cell Survival Interleukin-1beta
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The Interplay Between Epithelial-Mesenchymal Transition (EMT) and the Thyroid Hormones-αvβ3 Axis in Ovarian Cancer.

Hormones & cancer Dec 19, 2017
Ovarian cancer is a highly metastatic disease. The metastatic potential is enhanced by epithelial to mesenchymal transition (EMT) in which αvβ3 integrin plays a role. Thyroid hormones (L-thyroxine, T4, and 3,5,3'-triiodo-L-thyronine, T3) bind this in...
Integrin alphaVbeta3 Snail Family Transcription Factors Zinc Finger E-box-Binding Homeobox 1 Vimentin Signal Transduction Cadherins Triiodothyronine Ovarian Neoplasms Thyroid Hormones beta Catenin Epithelial-Mesenchymal Transition Female Thyroxine Humans Zonula Occludens-1 Protein Cell Line, Tumor Gene Expression Regulation, Neoplastic
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[Advances in mechanotransduction signaling pathways in distraction osteogenesis].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery Jul 15, 2025
OBJECTIVE: To review the role and research progress of mechanotransduction signaling pathway in distraction osteogenesis, so as to provide theoretical basis and reference for clinical treatment.
beta Catenin Bone Regeneration Humans Osteoblasts Signal Transduction Animals Transforming Growth Factor beta Ion Channels Smad Proteins Integrins Osteogenesis, Distraction Mechanotransduction, Cellular Osteogenesis Bone Morphogenetic Proteins
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Exploring the Mechanisms of Sanguinarine in the Treatment of Osteoporosis by Integrating Network Pharmacology Analysis and Deep Learning Technology.

Current computer-aided drug design Jan 1, 2025
BACKGROUND: Sanguinarine (SAN) has been reported to have antioxidant, antiinflammatory, and antimicrobial activities with potential for the treatment of osteoporosis (OP).
Humans Molecular Docking Simulation Deep Learning Protein Interaction Maps Osteoporosis Animals Benzophenanthridines Isoquinolines beta Catenin Network Pharmacology Mice Caspase 3
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Effects of Jiazhu decoction in combination with cyclophosphamide on breast cancer in mice.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Oct 1, 2019
OBJECTIVE: To investigate the therapeutic effects of Jiazhu decoction (JZD) in combination with cyclophosphamide (CTX) on the growth of breast cancer in mice and to explore the possible molecular mechanisms of action.
Cyclin D1 Cyclophosphamide Mice Genes, myc Drug Interactions Antineoplastic Agents RNA, Messenger beta Catenin Cell Proliferation Breast Neoplasms Xenograft Model Antitumor Assays Cell Line, Tumor Gene Expression Regulation, Neoplastic Drugs, Chinese Herbal Animals
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