AIMC Topic: Triazoles
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Unlocking the Potential: The Structural Wonders and Diverse Applications of Triazoles in Contemporary Science.
Topics in current chemistry (Cham)
Jul 4, 2025
Triazoles, a captivating class of nitrogen-containing heterocyclic compounds, have emerged as pivotal players in contemporary chemistry, drawing significant attention for their exceptional versatility and wide-ranging applications. They have become e...
Design, synthesis, and evaluation of triazolo[1,5-a]pyridines as novel and potent α‑glucosidase inhibitors.
Scientific reports
May 22, 2025
α-Glucosidase is a key enzyme responsible for controlling the blood glucose, making a pivotal target in the treatment of type 2 diabetes mellitus. Present work introducestriazolo[1,5-a]pyridine as a novel, potent scaffold for α-glucosidase inhibition...
Fusion features of microfluorescence hyperspectral imaging for qualitative detection of pesticide residues in Hami melon.
Food research international (Ottawa, Ont.)
Sep 4, 2024
Pesticide residues are identified as a significant food safety issue in Hami melons, and their rapid and accurate detection is deemed critical for ensuring public health. In response to the cumbersome procedures with existing chemical detection metho...
Synthesis, Docking, and Machine Learning Studies of Some Novel Quinolinesulfonamides-Triazole Hybrids with Anticancer Activity.
Molecules (Basel, Switzerland)
Jul 2, 2024
In the presented work, a series of 22 hybrids of 8-quinolinesulfonamide and 1,4-disubstituted triazole with antiproliferative activity were designed and synthesised. The title compounds were designed using molecular modelling techniques. For this pur...
Physiologically based kinetic (PBK) modeling of propiconazole using a machine learning-enhanced read-across approach for interspecies extrapolation.
Environment international
Jun 7, 2024
A significant challenge in the traditional human health risk assessment of agrochemicals is the uncertainty in quantifying the interspecies differences between animal models and humans. To work toward a more accurate and animal-free risk determinatio...
Adsorption simulation of 2,4-D pesticide on novel zinc-based 2-amino-4-(1H-1,2,4-triazole-4-yl)benzoic acid coordination complexes using machine learning approach.
Environmental science and pollution research international
May 17, 2024
The capacity of zinc-based 2-amino-4-(1H-1,2,4-triazole-4-yl)benzoic acid coordination complex (Zn(NH-TBA)) and modified Zn(NH-TBA)COMe complex for removal of 2,4-dichlorophenoxyacetic acid (2,4-D) from aqueous solutions was investigated through adso...
Binding Mechanism of Inhibitors to BRD4 and BRD9 Decoded by Multiple Independent Molecular Dynamics Simulations and Deep Learning.
Molecules (Basel, Switzerland)
Apr 19, 2024
Bromodomain 4 and 9 (BRD4 and BRD9) have been regarded as important targets of drug designs in regard to the treatment of multiple diseases. In our current study, molecular dynamics (MD) simulations, deep learning (DL) and binding free energy calcula...
Dynamic parametric MRI and deep learning: Unveiling renal pathophysiology through accurate kidney size quantification.
NMR in biomedicine
Dec 3, 2023
Renal pathologies often manifest as alterations in kidney size, providing a valuable avenue for employing dynamic parametric MRI as a means to derive kidney size measurements for the diagnosis, treatment, and monitoring of renal disease. Furthermore,...
A novel deep learning model DDU-net using edge features to enhance brain tumor segmentation on MR images.
Artificial intelligence in medicine
Sep 28, 2021
Glioma is a relatively common brain tumor disease with high mortality rate. Humans have been seeking a more effective therapy. In the course of treatment, the specific location of the tumor needs to be determined first in any case. Therefore, how to ...
Robotic Assay for Drought (RoAD): an automated phenotyping system for brassinosteroid and drought responses.
The Plant journal : for cell and molecular biology
Aug 10, 2021
Brassinosteroids (BRs) are a group of plant steroid hormones involved in regulating growth, development, and stress responses. Many components of the BR pathway have previously been identified and characterized. However, BR phenotyping experiments ar...
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