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Uncertainty

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Efficient Normalized Conformal Prediction and Uncertainty Quantification for Anti-Cancer Drug Sensitivity Prediction with Deep Regression Forests.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Deep learning models are being adopted and applied across various critical medical tasks, yet they are primarily trained to provide point predictions without providing degrees of confidence. Medical practitioner's trustworthiness of deep learning mod...

Optimizing Stroke Detection Using Evidential Networks and Uncertainty-Based Refinement.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Evaluating neurological impairments post-stroke is essential for assessing treatment efficacy and managing subsequent disabilities. Conventional clinical assessment methods depend largely on clinicians' visual and physical evaluations, resulting in c...

CatPred: a comprehensive framework for deep learning in vitro enzyme kinetic parameters.

Nature communications
Estimation of enzymatic activities still heavily relies on experimental assays, which can be cost and time-intensive. We present CatPred, a deep learning framework for predicting in vitro enzyme kinetic parameters, including turnover numbers (k), Mic...

Explainability and uncertainty: Two sides of the same coin for enhancing the interpretability of deep learning models in healthcare.

International journal of medical informatics
BACKGROUND: The increasing use of Deep Learning (DL) in healthcare has highlighted the critical need for improved transparency and interpretability. While Explainable Artificial Intelligence (XAI) methods provide insights into model predictions, reli...

Semi-supervised tissue segmentation from histopathological images with consistency regularization and uncertainty estimation.

Scientific reports
Pathologists have depended on their visual experience to assess tissue structures in smear images, which was time-consuming, error-prone, and inconsistent. Deep learning, particularly Convolutional Neural Networks (CNNs), offers the ability to automa...

A machine learning approach to feature selection and uncertainty analysis for biogas production in wastewater treatment plants.

Waste management (New York, N.Y.)
The growing demand for efficient waste management solutions and renewable energy sources has driven research into predicting biogas production at wastewater treatment plants. This study outlines a methodology starting with data collection from a full...

C-UQ: Conflict-based uncertainty quantification-A case study in lung cancer classification.

Computers in biology and medicine
Uncertainty quantification is crucial in deep learning, especially in medical diagnostics, to measure model prediction confidence and ensure reliable clinical decisions. This study introduces a novel conflict-based uncertainty quantification approach...

T-ALPHA: A Hierarchical Transformer-Based Deep Neural Network for Protein-Ligand Binding Affinity Prediction with Uncertainty-Aware Self-Learning for Protein-Specific Alignment.

Journal of chemical information and modeling
There is significant interest in targeting disease-causing proteins with small molecule inhibitors to restore healthy cellular states. The ability to accurately predict the binding affinity of small molecules to a protein target in silico enables the...

An accurate and trustworthy deep learning approach for bladder tumor segmentation with uncertainty estimation.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Although deep learning-based intelligent diagnosis of bladder cancer has achieved excellent performance, the reliability of neural network predicted results may not be evaluated. This study aims to explore a trustworthy AI-b...

CTUSurv: A Cell-Aware Transformer-Based Network With Uncertainty for Survival Prediction Using Whole Slide Images.

IEEE transactions on medical imaging
Image-based survival prediction through deep learning techniques represents a burgeoning frontier aimed at augmenting the diagnostic capabilities of pathologists. However, directly applying existing deep learning models to survival prediction may not...