OBJECTIVES: Multiple b-value gas diffusion-weighted MRI (DW-MRI) enables non-invasive and quantitative assessment of lung morphometry, but its long acquisition time is not well-tolerated by patients. We aimed to accelerate multiple b-value gas DW-MRI...
Pathophysiologic changes in lung diseases are often accompanied by changes in ventilation and gas exchange. Comprehensive evaluation of lung function cannot be obtained through chest X-ray and computed tomography. Proton-based lung MRI is particularl...
Magnetic resonance imaging (MRI) using hyperpolarized noble gases provides a way to visualize the structure and function of human lung, but the long imaging time limits its broad research and clinical applications. Deep learning has demonstrated grea...
PURPOSE: To evaluate the feasibility and utility of a deep learning (DL)-based reconstruction for improving the SNR of hyperpolarized Xe lung ventilation MRI.
RATIONALE AND OBJECTIVES: Hyperpolarized Xe MRI quantifies ventilation-defect-percent (VDP), the ratio of Xe signal-void to the anatomic H MRI thoracic-cavity-volume. VDP is associated with airway inflammation and disease control and serves as a trea...