This paper presents the development of a novel miniature electrical impedance tomography (EIT) system made out of glass, along with the training, validation, and testing of an accompanying open-source machine learning image reconstruction model. Our ...
Using machine learning, we developed models that rigorously detect and classify larval zebrafish spontaneous and stimulus-evoked behaviors in various well plate formats. Zebrafish are an ideal model system for investigating the neural substrates unde...
Precise assessment of toxicological effects remains a key bottleneck in biomedical and environmental health assessments. Traditional toxicology relies on macroscopic end points and manual image analysis, which limit sensitivity to structural damage a...
Brains evolve within specific sensory and physical environments, yet neuroscience has traditionally focused on studying neural circuits in isolation. Understanding of their function requires integrative brain-body testing in realistic contexts. To in...
Proceedings of the National Academy of Sciences of the United States of America
Oct 10, 2025
Adaptive differences in the thermal stabilities of enzyme structure and function play critical roles in establishing the thermal optima and limits of all organisms. Thus, understanding the mechanisms underlying these adaptations can yield insights in...
Computer vision and artificial intelligence (AI) have become increasingly important in behavioral analysis across biological research. In contrast to well-established methods for individual behavior analysis, computational frameworks for quantitative...
The heart is formed from diverse cell lineages that assemble into a functional unit, including the pericardium, a mesothelial sac that supports movement, homeostasis, and immune responses. However, its developmental origins remain unresolved. Here, w...
Hypophosphatasia (HPP) is a rare genetic disorder mainly affecting bone and tooth mineralization in patients due to ALPL gene mutations. Understanding genotype-phenotype correlations in HPP remains challenging due to different severities and the dise...
Journal of the American Chemical Society
Sep 3, 2025
Glutamate (Glu) plays a critical role in the brain, and the ability to directly measure glutamate activity is essential for understanding its physiological functions and pathological processes. Herein, we engineered a family of Glu sensors () based o...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Aug 14, 2025
Hyperspectral imaging, as an emerging medical imaging technology, offers significant potential in biomedical research due to its ability in capturing rich spectral information. An enhanced bi-branch network integrating graph convolutional network (GC...
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