Allergy

Transcriptome analysis reveals the potential role of neural factor EN1 for long-terms survival in estrogen receptor-independent breast cancer.

Breast cancer patients with estrogen receptor-negative (ERneg) status, encompassing triple negative breast cancer (TNBC) and human epidermal growth factor receptor 2 positive breast cancer, are confronted with a heightened risk of drug resistance, often leading to early recurrence; the biomarkers and biological processes associated with recurrence is still unclear. In this study, we analyzed bulk ...

Development of a MVI associated HCC prognostic model through single cell transcriptomic analysis and 101 machine learning algorithms.

Hepatocellular carcinoma (HCC) is an exceedingly aggressive form of cancer that often carries a poor prognosis, especially when it is complicated by the presence of microvascular invasion (MVI). Identifying patients at high risk of MVI is crucial for personalized treatment strategies. Utilizing the single-cell RNA-sequencing dataset (GSE242889) of HCC, we identified malignant cell subtypes associa...

GRATCR: Epitope-Specific T Cell Receptor Sequence Generation With Data-Efficient Pre-Trained Models.

T cell receptors (TCRs) play a crucial role in numerous immunotherapies targeting tumor cells. However, their acquisition and optimization present sig...

Discovery of mutations predictive of survival benefit from immunotherapy in first-line NSCLC: A retrospective machine learning study of IMpower150 liquid biopsy data.

Predictive biomarker identification in cancer treatment has traditionally relied on pre-defined analyses, limiting discoveries to expected biomarkers ...

Bidirectional Long Short-Term Memory (BiLSTM) Neural Networks with Conjoint Fingerprints: Application in Predicting Skin-Sensitizing Agents in Natural Compounds.

Skin sensitization, or allergic contact dermatitis, represents a critical end point in toxicity assessment, with profound implications for drug safety...

Machine learning analysis identified NNMT as a potential therapeutic target for hepatocellular carcinoma based on PCD-related genes.

Programmed cell death (PCD) plays a critical role in cancer biology, influencing tumor progression and treatment response. This study aims to investig...

Pretrained transformers applied to clinical studies improve predictions of treatment efficacy and associated biomarkers.

Cancer treatment has made significant advancements in recent decades, however many patients still experience treatment failure or resistance. Attempts...

Analytical and experimental solutions for Fourier transform infrared microspectroscopy measurements of microparticles: A case study on Quercus pollen.

BACKGROUND: FTIR microspectroscopy is a popular non-destructive technique for chemical analysis and identification of microparticles, such as micropla...

Modelling of pome fruit pollen performance using machine learning.

Agriculture, particularly fruit production, is considered a crucial industry with a significant economic impact in many countries. Extreme fluctuation...

Machine learning for early diagnosis of Kawasaki disease in acute febrile children: retrospective cross-sectional study in China.

Early diagnosis of Kawasaki disease (KD) allows timely treatment to be initiated, thereby preventing coronary artery aneurysms in children. However, i...

[MP-MRI in the evaluation of non-operative treatment response, for residual and recurrent tumor detection in head and neck cancer].

As non-surgical therapies gain acceptance in head and neck tumors, the importance of imaging has increased. New therapeutic methods (in radiation ther...

From text to insight: A natural language processing-based analysis of burst and research trends in HER2-low breast cancer patients.

With the intensification of population aging, the proportion of elderly breast cancer patients is continuously increasing, among which those with low ...

Integration of 101 machine learning algorithm combinations to unveil m6A/m1A/m5C/m7G-associated prognostic signature in colorectal cancer.

Colorectal cancer (CRC) is the most common malignancy in the digestive system, with a lower 5-year overall survival rate. There is increasing evidence...

Multi-omics and single-cell analysis reveals machine learning-based pyrimidine metabolism-related signature in the prognosis of patients with lung adenocarcinoma.

Pyrimidine metabolism is a hallmark of tumor metabolic reprogramming, while its significance in the prognostic and therapeutic implications of patien...

Development and validation of MRI-derived deep learning score for non-invasive prediction of PD-L1 expression and prognostic stratification in head and neck squamous cell carcinoma.

BACKGROUND: Immunotherapy has revolutionized the treatment landscape for head and neck squamous cell carcinoma (HNSCC) and PD-L1 combined positivity s...

CT-Based Deep Learning Predicts Prognosis in Esophageal Squamous Cell Cancer Patients Receiving Immunotherapy Combined with Chemotherapy.

RATIONALE AND OBJECTIVES: Immunotherapy combined with chemotherapy has improved outcomes for some esophageal squamous cell carcinoma (ESCC) patients, ...

A privacy-preserved horizontal federated learning for malignant glioma tumour detection using distributed data-silos.

Malignant glioma is the uncontrollable growth of cells in the spinal cord and brain that look similar to the normal glial cells. The most essential pa...

Multiple machine learning-based integrations of multi-omics data to identify molecular subtypes and construct a prognostic model for HNSCC.

BACKGROUND: Immunotherapy has introduced new breakthroughs in improving the survival of head and neck squamous cell carcinoma (HNSCC) patients, yet dr...

Two-stage CNN-based framework for leukocytes classification.

Leukocytes are pivotal markers in health, crucial for diagnosing diseases like malaria and viral infections. Peripheral blood smear tests provide path...

Machine learning-based integration reveals immunological heterogeneity and the clinical potential of T cell receptor (TCR) gene pattern in hepatocellular carcinoma.

The T Cell Receptor (TCR) significantly contributes to tumor immunity, whereas the intricate interplay with the Hepatocellular Carcinoma (HCC) microen...