Allergy

Identification of T-cell exhaustion-related biomarkers in aortic dissection via integrated multi-omics analysis and mendelian randomization.

BACKGROUND: Aortic dissection (AD) is a life-threatening cardiovascular emergency characterized by high acute mortality. While immune dysregulation is known to drive AD pathogenesis, the specific involvement of T-cell exhaustion-related genes (TEXRGs) remains largely elusive. METHODS: Differentially expressed TEXRGs (DETEXRGs) between AD and control samples were identified using transcriptomic dat...

Automated measurement of CD8+ T-cell distribution at the tumor epithelial-stromal interface is associated with NSCLC immunotherapy benefit and transcriptomic pathways.

Whereas anti-PD-(L)1 therapies are widely used in cancer treatment, only a subset of patients achieve long-term survival. Companion diagnostics based on PD-L1 expression have limited predictive power for these therapies, motivating development of additional predictive markers. We demonstrate a digital pathology (DP) method to quantify the density and epithelial infiltration of cytotoxic T cells ne...

Molecular characteristics and modifications of glioblastoma affecting the efficacy of immunotherapy.

Glioblastoma is a highly aggressive brain tumor characterized by complex genetic, molecular, and epigenetic features that present significant challeng...

Machine learning-based integration develops a novel lysosome-related prognostic signature associated with prognosis and immune infiltration landscape in acute myeloid leukemia.

BACKGROUND: Lysosomes are essential for intracellular degradation and recycling, and changes in their function significantly contribute to tumor growt...

A Two-Stage, Semi-Supervised Deep Learning Framework for the Detection and Classification of Ambient Pollen using Evanescent Wave Scattering.

Airborne pollen, an aeroallergen, impacts human health, particularly as climate change shifts pollen dynamics, requiring accurate monitoring to suppor...

Quality of AI chatbot-generated information on hypersensitivity pneumonitis for clinical and patient use.

BACKGROUND AND AIM: Hypersensitivity pneumonitis (HP) is a complex, immüne mediated interstitial lung disease in which accurate diagnosis and long ter...

From in silico screening to mechanism: computational advances in developing anti-allergic agents for food allergy.

Food allergy represents a significant global health concern with considerable socioeconomic impacts. While natural bioactive components offer promisin...

Scenario-based multi-parametric QC for quality control of complex algorithms used in clinical care.

Complex algorithms and prediction models are increasingly being developed, investigated and applied for clinical use in medical laboratories and beyon...

Expression of the High Affinity Neurotensin Receptor Defines an Immune‑cold, Poor‑prognosis Colorectal Cancer Subtype.

OBJECTIVE: We investigated neurotensin receptor 1 (NTSR1) as a potential mediator of the mechanical immune barrier that contributes to T-cell exclusio...

Bone marrow CCR3 dictates eosinophil lineage commitment of CD34⁺ progenitors to orchestrate allergic rhinitis: A composite study.

BACKGROUND: Allergic rhinitis (AR) is a common Th2-mediated inflammatory disease of the nasal mucosa, in which eosinophils serve as pivotal effector c...

Rational design of active pharmaceutical ingredient-based co-assembled nanoparticles for cancer immunotherapy.

Combination strategy is crucial for enhancing cancer therapeutic efficacy, but co-delivery of multiple active pharmaceutical ingredients (APIs) remain...

Single-cell and multi-omics integration delineates the landscape of gene-wise intratumor heterogeneity and identifies prognostic biomarkers for immunotherapy in non-small cell lung cancer.

BACKGROUND: Gene-wise intratumor heterogeneity (ITH), defined as spatial variability in the expression of individual genes across tumor regions, remai...

2-Hydroxyisobutyrylation and Phosphorylation Crosstalk Guides Metastasis Prediction and Immunotherapy in Esophageal Squamous Cell Carcinoma.

Posttranslational modification (PTM) is pivotal in cancer progression. However, the mechanisms, biological function, and clinical significance underly...

A Pollen-Enhanced Bionic Mechanoreceptor Induced by Asymmetric Ionic Convection in Hydrogel for Sensory-Augmented Prostheses.

The growing prevalence of age-related limb loss underscores the need for prosthetic technologies that restore not only motor function but also authent...

Small Molecules: What makes them 'small' and why is that important? What can we expect?

Just when newer technologies threaten to render them obsolete, small molecule drugs are under way to becoming first-in-class drugs in allergy and immu...

Exploring the immune landscape and immunotherapy relevance of ER stress-related lncRNAs in melanoma through multi-omics and explainable machine learning.

BACKGROUND: Melanoma is a highly aggressive malignancy with poor clinical outcomes, and endoplasmic reticulum (ER) stress plays an important role in t...

Dissecting T-cell exhaustion heterogeneity and immune ecosystem dynamics in colorectal cancer through multi-omics machine learning.

BACKGROUND: Immunotherapy has shown limited efficacy in a substantial subset of CRC patients, yet the mechanisms underlying therapeutic resistance rem...

Body composition radiomics integrated with machine learning to predict prognosis in advanced NSCLC treated with first-line immunochemotherapy and concurrent radiotherapy.

OBJECTIVE: Adipose tissue is a highly heterogeneous and plastic endocrine and immune organ whose characteristics have been linked to prognosis in NSCL...

Pathway-level epigenetic modeling illuminates the methylation architecture to asthma risk across tissues.

BACKGROUND: Asthma is a clinically heterogeneous airway disorder characterized by complex interactions between environmental exposures, immune activat...

Determinants of Poor Health-Related Quality of Life in Patients With Food Allergy.

BACKGROUND: Food allergy (FA) significantly impairs health-related quality of life (HRQL), yet its key determinants remain unclear. This study aimed t...