Flu & URI

Sustainable integration of artificial intelligence and machine learning approaches within the African infectious disease vaccine research and development ecosystem.

Artificial Intelligence and Machine Learning (AI/ML) techniques, including reverse vaccinology and predictive models, have already been applied for developing vaccine candidates for COVID-19, HIV, and Hepatitis, streamlining the vaccine development lifecycle from discovery to deployment. The application of AI and ML technologies for improving heath interventions, including drug discovery and clini...

Policy brief: Improving national vaccination decision-making through data.

Life course immunisation looks at the broad value of vaccination across multiple generations, calling for more data power, collaboration, and multi-disciplinary work. Rapid strides in artificial intelligence, such as machine learning and natural language processing, can enhance data analysis, conceptual modelling, and real-time surveillance. The GRADE process is a valuable tool in informing public...

Evaluating generative artificial intelligence's limitations in health policy identification and interpretation.

Policy epidemiology utilizes human subject-matter experts (SMEs) to systematically surface, analyze, and categorize legally-enforceable policies. The ...

A Pathological Diagnosis Method for Fever of Unknown Origin Based on Multipath Hierarchical Classification: Model Design and Validation.

BACKGROUND: Fever of unknown origin (FUO) is a significant challenge for the medical community due to its association with a wide range of diseases, t...

VaxOptiML: leveraging machine learning for accurate prediction of MHC-I and II epitopes for optimized cancer immunotherapy.

Cancer immunotherapy hinges on accurate epitope prediction for advancing vaccine development. VaxOptiML (available at https://vaxoptiml.streamlit.app/...

Using machine learning for personalized prediction of longitudinal coronavirus disease 2019 vaccine responses in transplant recipients.

The coronavirus disease 2019 pandemic has underscored the importance of vaccines, especially for immunocompromised populations like solid organ transp...

High-throughput Kinetics using capillary Electrophoresis and Robotics (HiKER) platform used to study T7, T3, and Sp6 RNA polymerase misincorporation.

T7 RNA Polymerase (RNAP) is a widely used enzyme with recent applications in the production of RNA vaccines. For over 50 years denaturing sequencing g...

Neural network procedures for the cholera disease system with public health mediations.

Severe gastrointestinal infections and watery diseases like cholera are still a major worldwide medical concern in the developing nations. A mathemati...

Evaluation of rapid detection methods for H5N1 virus using biosensors: An AI-based study.

High mortality and zoonotic potential predispose the H5N1 avian influenza virus as a critical threat. knowing that an epidemic could be occurring, qui...

Fair and explainable Myocardial Infarction (MI) prediction: Novel strategies for feature selection and class imbalance correction.

The rising incidences of myocardial infarction (MI), often affecting individuals without traditional risk factors, highlight the urgent need for impro...

Integrating Interpretability in Machine Learning and Deep Neural Networks: A Novel Approach to Feature Importance and Outlier Detection in COVID-19 Symptomatology and Vaccine Efficacy.

In this study, we introduce a novel approach that integrates interpretability techniques from both traditional machine learning (ML) and deep neural n...

Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines.

Next-generation T-cell-directed vaccines for COVID-19 focus on establishing lasting T-cell immunity against current and emerging SARS-CoV-2 variants. ...

-targeted AI-driven vaccines: a paradigm shift in gastric cancer prevention.

, a globally prevalent pathogen Group I carcinogen, presents a formidable challenge in gastric cancer prevention due to its increasing antimicrobial r...

A deep learning approach predicting the activity of COVID-19 therapeutics and vaccines against emerging variants.

Understanding which viral variants evade neutralization is crucial for improving antibody-based treatments, especially with rapidly evolving viruses l...

Current update on the neurological manifestations of long COVID: more questions than answers.

Since the outbreak of the COVID-19 pandemic, there has been a global surge in patients presenting with prolonged or late-onset debilitating sequelae o...

Artificial intelligence meets the world experts; updates and novel therapies in autoimmunity - The 14th international congress on autoimmunity 2024 (AUTO14), Ljubljana.

The bi-annual international congress on autoimmunity is a huge opportunity for the medical community to discuss the latest updates in the field. Durin...

Accuracy of Machine Learning in Discriminating Kawasaki Disease and Other Febrile Illnesses: Systematic Review and Meta-Analysis.

BACKGROUND: Kawasaki disease (KD) is an acute pediatric vasculitis that can lead to coronary artery aneurysms and severe cardiovascular complications,...

Machine learning algorithms for prediction of measles one vaccination dropout among 12-23 months children in Ethiopia.

INTRODUCTION: Despite the availability of a safe and effective measles vaccine in Ethiopia, the country has experienced recurrent and significant meas...

A Systematic Review and Meta-Analysis of the Efficacy of Biosecurity in Disease Prevention and Control in Livestock Farms in Africa.

In Africa, livestock production plays a crucial role for sustainable food security and economic growth. However, the development of this sector has be...

Protein-Protein Interaction Networks Derived from Classical and Machine Learning-Based Natural Language Processing Tools.

The study of protein-protein interactions (PPIs) provides insight into various biological mechanisms, including the binding of antibodies to antigens,...