Gastroenterology

Development of a machine learning-based noninvasive diagnostic model for liver fibrosis in metabolic-associated steatotic liver disease.

BACKGROUND: To address the lack of simple tools for assessing fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD), this study develops a machine learning-based diagnostic model to identify patients at high risk of significant fibrosis and advanced fibrosis. METHODS: Data from biopsy-proven MASLD patients were randomly divided into training and validation sets. Variables we...

Histological AI-Assisted Analysis Outperforms Pathologist Assessment in Predicting Disease Outcomes in PSC Patients.

AIMS: Liver biopsy has shown prognostic significance in primary sclerosing cholangitis (PSC). However, histology is typically assessed manually based on coarse grading scales, making precise quantification difficult. We developed a neural network model to address the key histological features of liver tissue, including portal tracts, fibrosis, biliary epithelium, portal inflammation, and vasculatu...

Impact of image reconstruction algorithms on histogram analysis of iodine concentration for assessing chemotherapy response in pancreatic ductal adenocarcinoma.

PURPOSE: To evaluate the impact of image reconstruction algorithms on histogram analysis of iodine concentration (IC) derived from dual-energy CT (DEC...

Neural networks improve repeatability of intravoxel incoherent motion (IVIM) parameter estimation in pancreatic diffusion-weighted MRI.

Intravoxel incoherent motion (IVIM) analysis in diffusion-weighted MRI (DWI-MRI) shows potential for characterizing pancreatic tissue, but its clinica...

Jianpi Bushen Qingchang Huashi formula alleviates DSS-induced colitis through butyrate-associated HDAC1 inhibition and Th17/Treg homeostasis.

ETHNOPHARMACOLOGICAL RELEVANCE: Jianpi Bushen Qingchang Huashi Formula (JBQHF) is a traditional Chinese medicine compound of nine herbal ingredients c...

End-to-End Clinical Validation of a Human-Supervised Large Language Model Agent for Enterprise Surgical Pathology Reporting.

Large language models (LLMs) show promise for text-based pathology tasks, yet most reported applications remain experimental, lack formal clinical val...

The Metabolite indole-3-acetic acid of Bacteroides ovatus ameliorates ovariectomy-induced bone loss by activating AhR and inhibiting oxidative stress.

Postmenopausal osteoporosis represents a systemic skeletal condition distinguished by diminished bone mass and heightened skeletal fragility. Emerging...

Rewiring immunometabolism in hepato-biliary-pancreatic cancers: Unraveling TME-mediated metabolic suppression and advancing next-generation immunotherapeutic approaches.

Hepato-biliary-pancreatic cancers, notorious for their pronounced heterogeneity and poor prognosis, continue to be a dominant factor in cancer-related...

Towards Precision Medicine in MASLD: Evolution of Disease Subtyping.

Traditional classifications of metabolic dysfunction-associated steatotic liver disease (MASLD) based on histology or biochemical traits are insuffici...

A multimodal artificial intelligence method for accurate diagnosis of autoimmune gastritis.

BACKGROUND: Autoimmune gastritis (AIG), a chronic inflammatory disease associated with various comorbidities and complications, is often subject to mi...

Benefit of Linked-Color Imaging in Artificial Intelligence-Assisted Diagnosis of Early Gastric Cancer: A Pilot Study With Propensity Score Adjustment.

BACKGROUND AND AIMS: Artificial intelligence (AI)-assisted endoscopy represents a promising approach for lesion detection, yet frequent false-positive...

Assessing the proinflammatory potential of sterile fecal microbiome filtrate from ulcerative colitis patients using an intestine-on-chip platform and automated image analysis.

BACKGROUND AND AIMS: Ulcerative colitis (UC) is characterized by disruptions of the gut microbiome and an exaggerated mucosal immune response in genet...

Combining Artificial Intelligence and Indocyanine Green-Dyed Gauze for Dual-Navigation in Minimally Invasive Gastrointestinal Surgery: A Preliminary Study.

This preliminary study evaluated the feasibility of a dual-navigation strategy that integrates artificial intelligence (AI)-assisted identification of...

Organelle proteomics of human, neonatal pig, healthy and diabetic mouse islets.

Pancreatic islets, in which β cells constitute 50%-80% of the endocrine mass, are the body's site for glucose-regulated insulin secretion. Pancreatic ...

Histology-derived prediction of a stromal remodeling program in pancreatic ductal adenocarcinoma with transcriptomic and spatial validation.

OBJECTIVE: To develop and validate a histology-based model for predicting a stromal stiffness-related molecular surrogate in pancreatic ductal adenoca...

Tissue Biology and the Biomechanics of Modern Gastrointestinal Stapling: Principles for Successful Surgical Stapling.

BackgroundThe integration of gastrointestinal (GI) tissue biology with modern stapler mechanics remains a critical gap in optimizing surgical outcomes...

DINCH induces intestinal toxicity through "ROS-ENO1-PA-lipid peroxidation" axis: An integrated approach combining network toxicology and experimental validation.

Cyclohexane-1,2-dicarboxylic acid diisononyl ester (DINCH), as a "green" alternative to phthalates, has been widely used in consumer products and indu...

Integrating single-cell and bulk transcriptomics to identify a SUMOylation-related prognostic signature and the oncogenic role of VPS72 in hepatocellular carcinoma.

INTRODUCTION: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy characterized by limited therapeutic options and significant cellular h...

Fusion Gene Detection Enhances Clinical Outcome Prediction of Hepatocellular Carcinoma Through Machine Learning Analyses.

Hepatocellular carcinoma is one of the most lethal malignancies for humans. Assessing the clinical outcomes of HCC remains challenging. In this study,...

The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells.

N: (1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPD-Q), a tire rubber antioxidant derivative, accumulates in air, soil, and water and ha...