Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Showing 1555-1575 of 11,060 articles
Integrated analysis of single-cell and bulk RNA-seq data identifies NR4A1-associated macrophages in immunoglobulin A nephropathy.

Immunoglobulin A nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, is cha...

Dec 2025 41447859
DSSA-PPI: enhancing binding affinity change prediction upon protein mutations using disentangled structure-sequence aware attention.

Accurate assessment of the effects of mutations on protein-protein interactions (PPIs) is crucial fo...

Dec 2025 41487137
Protein design and RNA design: Perspectives.

Advances in deep learning and generative modeling have transformed the landscape of protein and RNA ...

Dec 2025 41675592
Smooth Muscle Disruptive Feature Defines Molecular Subtyping, Risk Stratification, and Metastatic Potential in Prostate Cancer.

BACKGROUND: Smooth muscle (SM) invasion represents a critical feature of prostate cancer (PCa) progr...

Dec 2025 41428021
MLDeCNV: A machine learning approach for predicting copy number variation types in plant genomes.

Copy number variations (CNVs) play a crucial role in shaping genetic diversity and influencing vario...

Dec 2025 41435499
Dynamic Analysis of the Substrate Tolerance Mechanism and Domain Synergistic Engineering of CYP450 Fusion Protein (CYPLY).

CYP450 enzymes are important in natural product biosynthesis and industrial catalysis. A significant...

Dec 2025 41429466
From traditional to AI-driven: The evolution of intelligent enzyme engineering for biocatalysis.

Enzyme engineering involves enhancing enzyme function and application through multidimensional techn...

Dec 2025 41443357
EvoZymePro-Cat: A Protein-Ligand-Aware Deep Learning Framework for Predicting Mutation Effects in Enzyme Function.

Enzymes are biological catalysts that speed up chemical reactions in an eco-friendly way. Precise en...

Dec 2025 41422407
EGR1 promotes ferroptosis in endometriosis through transcriptional activation of HMOX1.

Endometriosis (EM) affects approximately 10% of women of reproductive age and remains a prevalent es...

Dec 2025 41422938
Integrating machine learning and functional genomics to study cross-species gene regulatory evolution.

Understanding the genetic basis of phenotypic differences across species has been a longstanding goa...

Dec 2025 41420926
Screening channelrhodopsins using robotic intracellular electrophysiology and single cell sequencing.

BACKGROUND: Our ability to engineer opsins is limited by an incomplete understanding of how sequence...

Dec 2025 41421605
scGImpute: A hybrid BiLayer multi-head graph attention-based imputation framework for zero dropout in single-cell sequencing datasets.

Single-cell sequencing (SCS) is a robust high-throughput sequencing technology used to measure RNA a...

Dec 2025 41435768
Calcium carbonate in drug delivery: functional carrier design, applications, and data-driven perspectives.

INTRODUCTION: Calcium carbonate particles are a very potent type of inorganic drug delivery carriers...

Dec 2025 41258700
Challenges in the diagnosis and management of hypertrophic cardiomyopathy and the promise of artificial intelligence.

Hypertrophic cardiomyopathy (HCM), the most prevalent inherited cardiomyopathy, is characterized by ...

Dec 2025 41421434
Pathway to precision: machine learning and bioinformatics in diabetes gene expression studies.

BACKGROUND: Diabetes mellitus is a metabolic disorder; understanding the pathogenic mechanisms under...

Dec 2025 41424950
Improving Genotype Imputation in High-Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches.

Multiple imputation is well-established for handling missing data, yet its use in high-dimensional g...

Dec 2025 41407383
TEWS: Transformer-empowered weakly supervised prediction of immune score and genetic mutations in liver cancer from whole slide image.

Whole Slide Imaging (WSI) plays a crucial role in predicting immune scores by providing detailed cel...

Dec 2025 41455181
HeptaTB Dx: a diagnostic model leveraging cuproptosis-ferroptosis crosstalk for distinguishing latent from active tuberculosis.

UNLABELLED: Distinguishing latent tuberculosis infection (LTBI) from active tuberculosis (ATB) remai...

Dec 2025 41405396
MetIoR: A meta predictor to predict intrinsic disorder in RNA binding proteins.

Intrinsic disorder in proteins is ubiquitous in nature across various proteomes. The association of ...

Dec 2025 41419011
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