Hematology

Repeated intravesical injections of platelet-rich plasma are effective in the treatment of interstitial cystitis: a case control pilot study.

OBJECTIVE: Interstitial cystitis (IC), also known as bladder pain syndrome (BPS), is a debilitating chronic disease. There are few treatment options for IC/BPS refractory to current medical therapy. This study investigated the clinical efficacy of intravesical injections of platelet-rich plasma (PRP) in IC/BPS.

Determination of Seminal Concentration of Fingolimod and Fingolimod-Phosphate in Multiple Sclerosis Patients Receiving Chronic Treatment With Fingolimod.

The safety profile of fingolimod 0.5 mg, approved therapy for relapsing multiple sclerosis, is well established in clinical and real-world studies. As fingolimod is teratogenic in rats, it was considered important to assess the concentrations of fingolimod and its active metabolite, fingolimod-phosphate, in the semen of male patients on treatment and the risk of harming a fetus in a pregnant partn...

Topical Tranexamic Acid Reduces Blood Loss in Minimally Invasive Total Knee Arthroplasty Receiving Rivaroxaban.

BACKGROUND: It is unclear whether topical (intra-articular) or intravenous TXA reduces blood loss in minimally invasive TKA patients receiving a direc...

Identifying the Presence of Prostate Cancer in Individuals with PSA Levels <20 ng ml Using Computational Data Extraction Analysis of High Dimensional Peripheral Blood Flow Cytometric Phenotyping Data.

Determining whether an asymptomatic individual with Prostate-Specific Antigen (PSA) levels below 20 ng ml has prostate cancer in the absence of defini...

Fast and easy extraction of antidepressants from whole blood using ionic liquids as extraction solvent.

This study aims to prove that ionic liquids (ILs) can be used as extraction solvents in a liquid-liquid microextraction, coupled to LC-MS/MS, for the ...

Label-free sensor for automatic identification of erythrocytes using digital in-line holographic microscopy and machine learning.

Cell types of erythrocytes should be identified because they are closely related to their functionality and viability. Conventional methods for classi...

Modeling the control of the central nervous system over the cardiovascular system using support vector machines.

The control of the central nervous system (CNS) over the cardiovascular system (CS) has been modeled using different techniques, such as fuzzy inducti...

Efficacy of Platelet-Rich Plasma on Fat Grafts in the Repair of Tympanic Membrane Perforations: An Experimental Study.

OBJECTIVE: We investigated the use of autologous platelet-rich plasma (PRP) to improve the success rate of fat graft myringoplasty in perforated tympa...

Validation of a definition of excessive postoperative bleeding in infants undergoing cardiac surgery with cardiopulmonary bypass.

OBJECTIVE: To derive and validate an objective definition of postoperative bleeding in neonates and infants undergoing cardiac surgery with cardiopulm...

Distinguishing three subtypes of hematopoietic cells based on gene expression profiles using a support vector machine.

Hematopoiesis is a complicated process involving a series of biological sub-processes that lead to the formation of various blood components. A widely...

Netrin-1 Ameliorates Blood-Brain Barrier Impairment Secondary to Ischemic Stroke via the Activation of PI3K Pathway.

Secondary impairment of blood-brain barrier (BBB) occurs in the remote thalamus after ischemic stroke. Netrin-1, an axonal guidance molecule, presents...

Cyanobacterium removal and control of algal organic matter (AOM) release by UV/HO pre-oxidation enhanced Fe(II) coagulation.

Harmful algal blooms in source water are a worldwide issue for drinking water production and safety. UV/HO, a pre-oxidation process, was firstly appli...

High-Dose Vitamin D Administration Is Associated With Increases in Hemoglobin Concentrations in Mechanically Ventilated Critically Ill Adults: A Pilot Double-Blind, Randomized, Placebo-Controlled Trial.

BACKGROUND: Anemia and vitamin D deficiency are highly prevalent in critical illness, and vitamin D status has been associated with hemoglobin concent...

White blood cell differential count of maturation stages in bone marrow smear using dual-stage convolutional neural networks.

The white blood cell differential count of the bone marrow provides information concerning the distribution of immature and mature cells within matura...

Increased Cardiovascular Risk in Patients with Adrenal Insufficiency: A Short Review.

Cardiovascular disease (CVD) is the most common cause of death in the world. Recent studies have shown an association between adrenal insufficiency (A...

Evaluation of Aristolochia indica L. and Piper nigrum L. methanol extract against centipede Scolopendra moristans L. using Wistar albino rats and screening of bioactive compounds by high pressure liquid chromatography: a polyherbal formulation.

The present study was aimed to explore the anti-venom activity of Aristolochia indica and Piper nigrum plants against the centipede (Scolopendra moris...

l-Carnosine supplementation attenuated fasting glucose, triglycerides, advanced glycation end products, and tumor necrosis factor-α levels in patients with type 2 diabetes: a double-blind placebo-controlled randomized clinical trial.

Considering the pathologic importance of metabolic disturbances, advanced glycation end products (AGEs), and chronic inflammation in diabetes mellitus...

White blood cells identification system based on convolutional deep neural learning networks.

BACKGROUND AND OBJECTIVES: White blood cells (WBCs) differential counting yields valued information about human health and disease. The current develo...

Convolutional neural network-based malaria diagnosis from focus stack of blood smear images acquired using custom-built slide scanner.

The present paper introduces a focus stacking-based approach for automated quantitative detection of Plasmodium falciparum malaria from blood smear. F...

Efficacy of Long-Term Oral Vitamin B12 Supplementation after Total Gastrectomy: Results from a Prospective Study.

BACKGROUND/OBJECTIVES: Vitamin B (VB12) deficiency is a common complication after total gastrectomy which may be associated with megaloblastic anemia ...