Hepatitis

Overview of recent strategic advances in antiviral covalent inhibitors.

Targeted covalent inhibitors (TCIs) have emerged as a promising antiviral modality, functioning through irreversible or reversible modification of conserved nucleophilic residues within essential viral proteins. These agents are increasingly recognized in antiviral drug discovery due to their potential to achieve enhanced target engagement and prolonged pharmacological effects when appropriately d...

AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling.

BACKGROUND: Ferroptosis plays a critical role in immune regulation and tumor microenvironment remodeling. However, its therapeutic potential in enhancing immune checkpoint inhibitor (ICI) efficacy remains incompletely understood and warrants further investigation. METHODS: To investigate the potential of ferroptosis in improving ICI response, we constructed a machine learning-based predictive mode...

Unexpected Applications of AlphaFold in Molecular Sciences.

AlphaFold, a groundbreaking artificial intelligence model developed by DeepMind, has transformed the field of structural biology by predicting protein...

The adaptive large language models for vaccine prediction: A novel approach to vaccine demand prediction with engineered deviation prompts.

Accurate vaccine demand forecasting is crucial for minimizing wastage and ensuring efficient immunization programs. In this study, we introduce an Ada...

Prognostic nomogram for recurrence free survival in elderly patients with HBV related hepatocellular carcinoma and diabetes from a multicenter study.

CRISPR-Cas12a/Cas13a in cancer molecular diagnosis.

Cancer remains a leading cause of global mortality, with early diagnosis being pivotal for improving treatment outcomes. Traditional tissue biopsy is ...

Overcoming gastrointestinal mucosal barriers: Mechanistic innovations and technical advances in mucosal targeting strategies for animal oral vaccines.

Infectious diseases caused by pathogenic microorganisms (such as Escherichia coli, Avian influenza virus (AIV), Rotavirus, etc.) that primarily invade...

Predicting VRE Infection After Liver Transplantation With a Time-Updated Colonization Score.

BACKGROUND: Vancomycin-resistant Enterococcus (VRE) infection is a life-threatening complication after liver transplantation (LT). This study aimed to...

NatProCP: A plant-derived natural products database for crop protection targeting SDH1 protein of Magnaporthe oryzae.

Research on natural products has grown rapidly in recent years, with various therapeutic compounds reported in the scientific literature for preventin...

Cross-Cultural Differences in Public Discourse on COVID-19 Vaccination in the United States and South Korea: Cross-Sectional Analysis Using Natural Language Processing.

BACKGROUND: The COVID-19 vaccine was introduced as a crucial tool to combat the pandemic. However, concerns about its effectiveness, side effects, and...

Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases.

Accessible liquid biopsies, including analyses of genome-wide cell-free DNA (cfDNA) fragmentation, are emerging for early detection of cancer but rema...

Exploring the impact of reimbursement ratios on willingness to vaccinate: A mixed-effects modeling approach using panel data.

Vaccination remains one of the most cost-effective methods for disease prevention. However, utilization of self-paid vaccines, including EV71, varicel...

YTHDF2 promotes m6A-modified HSPA2 translation to restrict Newcastle Disease Virus.

Newcastle disease virus (NDV), a highly contagious avian pathogen, causes devastating economic losses in poultry worldwide, yet the role of epitranscr...

Proteomics-based machine learning model for predicting secondary infection in HBV-related liver failure.

Patients with Hepatitis B Virus-related liver failure are highly vulnerable to secondary infections (SI), yet early predictive tools remain limited. I...

Pharmacological stabilization of hypoxia-inducible factor 1-α dampens the interferon response and promotes glycolysis in Aicardi-Goutières syndrome.

Aicardi-Goutières syndrome (AGS) is a genetic type I interferon (IFN)-mediated disease characterized by neurological involvement with onset in utero o...

Predicting short-term mortality in severe cirrhosis: An interpretable machine learning model integrating routine clinical indicators.

BACKGROUND: The critical need for precise risk stratification in severe liver cirrhosis is underscored by its substantial 30-day mortality rates, dema...

Multi-omics profiling reveals cholic acid-mediated immunosuppression driven by peritumoral ductular reactions in hepatocellular carcinoma.

Hepatocellular carcinoma remains a leading cause of cancer mortality worldwide, with peritumoral microenvironment interactions playing a critical role...

Potent efficacy of an NA-targeting antibody against a broad spectrum of H5N1 influenza viruses.

For nearly 30 years, Goose/Guangdong-derived highly pathogenic avian influenza H5N1 viruses have posed significant risks to economic stability, food s...

Tape-assisted nanoplasmonic biosensors for facile protein-on-chip visualization and multiplexed point-of-care diagnostics.

Visual point-of-care testing (POCT) technologies convert biomolecular events into naked-eye readable signals. These systems offer rapid assay times, u...

New treatments to rabies virus infections.

Rabies disease is the deadliest of all virus infections. Till now, vaccination is the most effective and reliable treatment for controlling rabies. Ho...