Infectious Disease

Hepatitis

Latest AI and machine learning research in hepatitis for healthcare professionals.

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Partial Inhibition of Viral Replication Machinery Enhances Recombination in Herpes Simplex Viruses

Herpes simplex viruses (HSV-1 and HSV-2) are widespread human pathogens, most commonly causing oral ...

Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions

The striatal direct and indirect pathways constitute the core for basal ganglia function in action c...

Automating Candidate Gene Prioritization with Large Language Models: From Naive Scoring to Literature-Grounded Validation

Identifying promising therapeutic targets from thousands of genes in transcriptomic studies remains ...

Hollow-fibre biomanufacturing and cell-free engineering of HEK293 extracellular vesicles

Extracellular vesicles (EVs) are lipid-delineated nanoparticles that are produced by most cell types...

OmniPath: integrated knowledgebase for multi-omics analysis

Analysis and interpretation of omics data largely benefit from the use of prior knowledge. However, ...

Discovery of RdRp Thumb-1 as a novel broad-spectrum antiviral family of targets and MDL-001 as a potent broad-spectrum inhibitor thereof

Multiple positive-sense, single-stranded RNA (+ssRNA) viruses cause human diseases, ranging from mil...

Structurally Informed Fitness Landscapes for Surveillance of Emerging PRRSV Variants

Antibodies play a central role in neutralizing pathogens through direct interference with viral entr...

Integrating Mutation and Stop Signals for Improved RNA Structure Analysis and Insight Discovery

Understanding RNA structures is essential for exploring its diverse cellular roles. Chemical modific...

Scaling Large Language Models for Next-Generation Single-Cell Analysis

Single-cell RNA sequencing has transformed our understanding of cellular diversity, yet current sing...

Computational Design of Miniprotein Binders Targeting the Viral Entry in Chikungunya and Dengue, Neglected Tropical Diseases

Neglected Tropical Diseases (NTDs) continue to be a global health concern, affecting millions worldw...

The mechanical code of DNA impacts its interaction with DNA gyrase

DNA:protein interactions involving large structural deformations of DNA underpin essential biologica...

An Immuno-Linguistic Transformer for Multi-Scale Modeling of T-Cell Spatiotemporal Dynamics

Understanding the spatiotemporal dynamics of T-cell clones is a critical challenge in immunology and...

A study on edge devices for image classification of the Tasmanian devil (Sarcophilus harrisii) for vaccine delivery

A target-specific bait dispenser is required for oral bait vaccination of the endangered Tasmanian d...

Systems biology framework for rational design of operational conditions for in vitro / in vivo translation of microphysiological systems

Preclinical models are used extensively to study diseases and potential therapeutic treatments. Comp...

ppLM-CO:Pre-trained Protein Language Model for Codon Optimization

Messenger ribonucleic acid (mRNA) vaccines represent a major advancement in synthetic biology, yet t...

SignalGen: A Protein Language Model Based AI Agent For Optimal Signal Peptide Prediction

Signal peptides are short amino acid sequences attached to the N-termini of mature proteins. They pl...

Iterative immunogen optimization to focus immune responses on a conserved, subdominant viral epitope

Designing effective vaccination strategies against genetically diverse viruses, such as HIV or influ...

Ultrahigh throughput screening to train generative protein models for engineering specificity into unspecific peroxygenases

Enzyme engineering is central to developing biocatalysts with improved activity and specificity, yet...

Viral protease-Initiated Pyroptosis Activator mRNA therapy as a Universal Antiviral Strategy

Although therapeutic drugs targeting gasdermin (GSDM)-mediated pyroptosis have made remarkable progr...

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