Myeloma

Machine Learning and Molecular Modeling Reveal HDAC6 as a Key Target of Tanshinone IIA in Multiple Myeloma.

Multiple myeloma (MM) is a malignant blood cancer marked by severe bone destruction and immune microenvironment disruption. Yet relapse and drug resistance remain major clinical challenges. Tanshinone IIA (TIIA) exhibits potent antitumor activity, but its molecular targets and mechanisms in MM remain unclear. Here, we systematically elucidate TIIA's pharmacological mechanisms in MM using network p...

Association Between the Dietary Inflammatory Index and Cardiorenal Anemia Syndrome: Evidence From NHANES and Related-Phenotype Exploration in KNHANES.

Cardiorenal anemia syndrome (CRAS) links heart failure, chronic kidney disease, and anemia, but the role of diet-related inflammation remains unclear. In the National Health and Nutrition Examination Survey (NHANES), we examined associations of the Dietary Inflammatory Index (DII) with CRAS, dose-response patterns, inflammatory mediation, and machine-learning prediction, alongside analysis of a my...

Antibiotic Resistance in Helicobacter pylori: Pathogenic Mechanisms and Eradication Barriers.

Antibiotic resistance in Helicobacter pylori is an important factor in the ineffectiveness of eradication regimens. The rate of resistance is not cons...

Explainable artificial intelligence reveals key surgical parameters in robot-assisted and open radical prostatectomy.

Preoperative risk stratification for radical prostatectomy is crucial, yet predicting the wide range of postoperative outcomes remains a significant c...

AI-assisted MALDI-TOF MS for identifying carbapenem resistance in clinical Acinetobacter baumannii isolates.

Carbapenem-resistant Acinetobacter baumannii (CRAB) is one of the most critical public health threats worldwide due to its high infection rates, subst...

Single-cell and bulk transcriptomic profiling of M2-like tumor-associated macrophages reveals a prognostic signature and an inflammation-metabolism crosstalk program in multiple myeloma.

BACKGROUND: M2-like tumor-associated macrophages (TAMs) contribute to multiple myeloma (MM) progression and treatment resistance, yet their internal h...

Hematopoietic stem cell aging: a review of transcriptional and multi-omics insights and potential paths for AI integration.

Hematopoietic stem cell (HSC) aging underlies age-related immune decline, anemia and increased risk of hematologic malignancies, including clonal hema...

Radiotherapy and immunotherapy in cancer treatment: mechanisms of clinical synergy.

Synergizing radiotherapy (RT) with immune checkpoint inhibitors has emerged as a promising strategy for solid tumors. RT acts as a potent immunomodula...

Development and validation of a Bayesian network-based surgical risk-prediction tool for patients with small-bowel stricturing Crohn's disease.

BACKGROUND: Patients with small-bowel stricturing Crohn's disease (sbsCD) usually have a higher risk of intestinal surgical resection. We aimed to dev...

Explainable machine learning for predicting childhood anemia in Sub-Saharan Africa using population-based DHS Data (2016-2024).

Childhood anemia remains a major public health challenge in Sub-Saharan Africa, adversely affecting physical growth, cognitive development, and child ...

Precision Medicine in Transfusion-Dependent and Non-Transfusion-Dependent β-Thalassemia: Toward Personalized Diagnosis and Therapy.

β-thalassemia comprises a clinically heterogeneous group of disorders in which anemia severity, transfusion exposure, iron loading, and organ complica...

Integrative multi-omics and machine learning identify CHRNA1 putative circadian-immune hub in COPD.

BACKGROUND: Circadian rhythm disruption is increasingly recognized as a contributor to chronic inflammatory disorders; however, its specific significa...

The deep learning radiomics nomogram for risk stratification in multiple myeloma using automatic whole-body [18F]FDG PET/CT segmentation approach.

PURPOSE: To develop a deep learning (DL) approach for automatic segmentation and accurate risk stratification in multiple myeloma (MM) using whole-bod...

AI-augmented MALDI-TOF MS screening reveals a high burden of undiagnosed monoclonal gammopathy in adult patients.

Monoclonal gammopathy of undetermined significance is a common precursor of multiple myeloma, yet its prevalence and clinical distribution remain poor...

Predictor Of Mortality In Obstructive Sleep Apnoea: Results of Explainable Deep Learning based Survival Analysis From a 15-Year Follow-Up.

INTRODUCTION: Obstructive sleep apnoea (OSA) is a respiratory disorder with comorbidities of several nature, from cardiovascular to renal ones. OSA is...

Establishment of a Multimodal Prognostic Prediction Model for Multiple Myeloma Patients Based on Radiomics and Clinical Features: A Retrospective Cohort Study.

OBJECTIVE: We aimed to develop a survival prediction system integrating radiomics and clinical features for newly diagnosed multiple myeloma (MM), and...

Personalized survival prediction in elderly dialysis patients: integrating machine learning with traditional survival analysis.

BACKGROUND: Elderly patients undergoing kidney replacement therapy (KRT) face high mortality rates. Traditional statistical models describe overall su...

An ensemble machine learning approach for predicting anemia among under-five children in malaria-endemic sub-Saharan African countries.

BACKGROUND: Worldwide, anemia in children under-five is a major public health issue, particularly in sub-Saharan Africa. Sub-Saharan Africa also has t...

Artificial Intelligence for Evidence Synthesis of Emerging Biologics to Improve Skeletal Health in Osteogenesis Imperfecta: Systematic Review and Meta-Analysis.

BACKGROUND: Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by bone fragility and recurrent fractures. Emerging biologics demons...

LWF-YOLO: a lightweight framework based YOLO for blood cell detection.

Accurate detection of blood cells-red blood cells, white blood cells, and platelets-is essential for diagnosing hematological disorders such as anemia...