Pancreatic Diseases

PBN11-8, a Cytotoxic Polypeptide Purified from Marine , Suppresses Invasion and Migration of Human Hepatocellular Carcinoma Cells by Targeting Focal Adhesion Kinase Pathways.

The development of antitumor drugs has attracted cancer researchers and the identification of novel antitumor lead compounds is certainly of great interest. The fermentation broth of sp. N11-8, which was isolated from the Antarctic waters, showed cytotoxicity towards different cells. A cytotoxic polypeptide, PBN11-8, was purified from the fermentation broth of sp. N11-8 using ultrafiltration, am...

Machine learning improves classification of preclinical models of pancreatic cancer with chemical exchange saturation transfer MRI.

PURPOSE: We sought to assess whether machine learning-based classification approaches can improve the classification of pancreatic tumor models relative to more simplistic analysis methods, using T relaxation, CEST, and DCE MRI.

Consumption of illegal home-made alcohol in Malawi: A neglected public health threat.

This study assessed the ethanol and methanol contents of homemade spirit (Kachasu) sold in Blantyre, Malawi. The likelihood of ethanol and methanol to...

Effect of daily intake of a low-alcohol orange beverage on cardiovascular risk factors in hypercholesterolemic humans.

Oxidative stress, inflammation status, endothelial dysfunction, and imbalanced lipid metabolism play a major role in cardiovascular disease. Bioactive...

Neural network-based model predictive control for type 1 diabetic rats on artificial pancreas system.

Artificial pancreas system (APS) is a viable option to treat diabetic patients. Researchers, however, have not conclusively determined the best contro...

Selective Oxidation of Biomass-Derived Alcohols and Aromatic and Aliphatic Alcohols to Aldehydes with O/Air Using a RuO-Supported MnO Catalyst.

Selective catalytic oxidation of carbohydrate-derived 5-hydroxymethylfurfural, furfuryl alcohol, and various aromatic and aliphatic compounds to the c...

Machine learning algorithm-based risk prediction model of coronary artery disease.

In view of high mortality associated with coronary artery disease (CAD), development of an early predicting tool will be beneficial in reducing the bu...

Proactive expert system intervention to prevent or quit at-risk alcohol use (PRINT): study protocol of a randomized controlled trial.

BACKGROUND: The population impact of alcohol screening and brief intervention might be increased by approaching an entire population rather than indiv...

Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism.

BACKGROUND: A statistical pipeline was developed and used for determining candidate genes and candidate gene coexpression networks involved in 2 alcoh...

Glucagonoma and Glucagonoma Syndrome: One Center's Experience of Six Cases.

Glucagonoma is an extremely rare neuroendocrine tumor arising from pancreatic islet cells. Although patients with glucagonoma manifest multiple typic...

Hierarchical combinatorial deep learning architecture for pancreas segmentation of medical computed tomography cancer images.

BACKGROUND: Efficient computational recognition and segmentation of target organ from medical images are foundational in diagnosis and treatment, espe...

Identifying tumor in pancreatic neuroendocrine neoplasms from Ki67 images using transfer learning.

The World Health Organization (WHO) has clear guidelines regarding the use of Ki67 index in defining the proliferative rate and assigning grade for pa...

Successful bystander-administered intranasal naloxone reversal of opioid overdose between two veterans: A case report.

Opioid overdose-related morbidity and mortality remain one of the most pressing public health crises. Overdose education and naloxone distribution hav...

An application of cascaded 3D fully convolutional networks for medical image segmentation.

Recent advances in 3D fully convolutional networks (FCN) have made it feasible to produce dense voxel-wise predictions of volumetric images. In this w...

Spatial aggregation of holistically-nested convolutional neural networks for automated pancreas localization and segmentation.

Accurate and automatic organ segmentation from 3D radiological scans is an important yet challenging problem for medical image analysis. Specifically,...

Decoding diagnosis and lifetime consumption in alcohol dependence from grey-matter pattern information.

OBJECTIVE: We investigated the potential of computer-based models to decode diagnosis and lifetime consumption in alcohol dependence (AD) from grey-ma...

Delirium Prediction using Machine Learning Models on Preoperative Electronic Health Records Data.

Electronic Health Records (EHR) are mainly designed to record relevant patient information during their stay in the hospital for administrative purpos...

Carboxybetaine-modified succinylated chitosan-based beads encourage pancreatic β-cells (Min-6) to form islet-like spheroids under in vitro conditions.

In vitro, pancreatic β-cells tend to reduce their ability to aggregate into islets and lose insulin-producing ability, likely due to insufficient cell...

Pro-inflammatory cytokines after an episode of acute pancreatitis: associations with fasting gut hormone profile.

INTRODUCTION: Pro-inflammatory cytokines, such as interleukin (IL)-6, tumour necrosis factor (TNF)α, and monocyte chemoattractant protein (MCP)-1, are...

Depression and alcohol use disorder at antiretroviral therapy initiation led to disengagement from care in South Africa.

We sought to assess mental health at the time of antiretroviral therapy (ART) initiation and subsequent retention in care over a six-month follow-up p...