Peptic Ulcer Disease

Towards Extracting Supporting Information About Predicted Protein-Protein Interactions.

One of the goals of relation extraction is to identify protein-protein interactions (PPIs) in biomedical literature. Current systems are capturing binary relations and also the direction and type of an interaction. Besides assisting in the curation PPIs into databases, there has been little real-world application of these algorithms. We describe UPSITE, a text mining tool for extracting evidence i...

Edoxaban vs warfarin in patients with nonvalvular atrial fibrillation in the US Food and Drug Administration approval population: An analysis from the Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) trial.

BACKGROUND: Edoxaban is a specific anti-Xa inhibitor that, in comparison to warfarin, has been found to be noninferior for the prevention of stroke or systemic embolism (SSE) and to reduce bleeding significantly in patients with nonvalvular atrial fibrillation (AF). The US Food and Drug Administration (FDA) approved the higher-dose edoxaban regimen (60/30 mg) in patients with AF and a creatinine c...

Percutaneous debridement and washout of walled-off abdominal abscess and necrosis using flexible endoscopy: a large single-center experience.

BACKGROUND AND STUDY AIMS: Direct percutaneous endoscopic necrosectomy has been described as a minimally invasive intervention for the debridement of ...

An experimental study to assess the best maneuver when using a reverse side-bevel histology needle for EUS-guided fine-needle biopsy.

BACKGROUND AND STUDY AIMS: Recently, ProCore™ was developed as an endoscopy ultrasound (EUS)-guided histology needle designed to address several curre...

Serum concentrations of clarithromycin and rifampicin in pulmonary Mycobacterium avium complex disease: long-term changes due to drug interactions and their association with clinical outcomes.

BACKGROUND: Concomitant use of clarithromycin (CAM) and rifampicin (RFP) for the treatment of pulmonary Mycobacterium avium complex (MAC) disease affe...

Prediction of Protein-Protein Interaction Sites with Machine-Learning-Based Data-Cleaning and Post-Filtering Procedures.

Accurately predicting protein-protein interaction sites (PPIs) is currently a hot topic because it has been demonstrated to be very useful for underst...

Scintigraphic Small Intestinal Transit Time and Defaecography in Patients with J-Pouch.

Objective methods for examination of pouch function are warranted for a better understanding of the functional result and treatment of dysfunction. Th...

Beating Heart Minimally Invasive Mitral Valve Surgery in Patients With Patent Coronary Bypass Grafts.

BACKGROUND: Redo mitral valve surgery in patients with patent coronary bypass grafts carries a risk of graft injury and postoperative bleeding. We com...

Computational probing protein-protein interactions targeting small molecules.

MOTIVATION: With the booming of interactome studies, a lot of interactions can be measured in a high throughput way and large scale datasets are avail...

IAS: Interaction Specific GO Term Associations for Predicting Protein-Protein Interaction Networks.

Proteins carry out their function in a cell through interactions with other proteins. A large scale protein-protein interaction (PPI) network of an or...

Protein complex detection in PPI networks based on data integration and supervised learning method.

BACKGROUND: Revealing protein complexes are important for understanding principles of cellular organization and function. High-throughput experimental...

Statistical Machines for Trauma Hospital Outcomes Research: Application to the PRospective, Observational, Multi-Center Major Trauma Transfusion (PROMMTT) Study.

Improving the treatment of trauma, a leading cause of death worldwide, is of great clinical and public health interest. This analysis introduces flexi...

Prediction of Outcome in Acute Lower Gastrointestinal Bleeding Using Gradient Boosting.

BACKGROUND: There are no widely used models in clinical care to predict outcome in acute lower gastro-intestinal bleeding (ALGIB). If available these ...

Benign Prostatic Hyperplasia Treatment by Transurethral Enucleation of the Prostate Using a 2-μm Laser.

This study investigates the efficacy of benign prostatic hyperplasia (BPH) treatment by prostate transurethral enucleation using a 2-μm laser. A total...

Comparative Analysis of Phenolics, Flavonoids, and Antioxidant and Antibacterial Potential of Methanolic, Hexanic and Aqueous Extracts from Adiantum caudatum Leaves.

In the quest for new medicines, the methanolic, hexanic, and aqueous extracts of Adiantum caudatum leaves, obtained by Soxhlet extraction, were analyz...

Design of wormlike automated robotic endoscope: dynamic interaction between endoscopic balloon and surrounding tissues.

BACKGROUND: The current design of capsule endoscope is limited by the inability to control the motion within gastrointestinal tract. The rising incide...

Iatrogenic Uterine Diverticulum in Pregnancy After Robotic-assisted Myomectomy.

Uterine diverticula are rare outpouchings of the uterus associated with abnormal uterine bleeding, pelvic pain, dysmenorrhea, and adverse obstetric ev...

Exploring the relationship between hub proteins and drug targets based on GO and intrinsic disorder.

Protein-protein interactions (PPIs) play essential roles in many biological processes. In protein-protein interaction networks, hubs involve in number...

Prediction of cancer proteins by integrating protein interaction, domain frequency, and domain interaction data using machine learning algorithms.

Many proteins are known to be associated with cancer diseases. It is quite often that their precise functional role in disease pathogenesis remains un...

Efficient prediction of progesterone receptor interactome using a support vector machine model.

Protein-protein interaction (PPI) is essential for almost all cellular processes and identification of PPI is a crucial task for biomedical researcher...