Rheumatology

Latest AI and machine learning research in rheumatology for healthcare professionals.

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An MOF-Enhanced Anti-Fouling Immunoprobe Platform for Efficient Direct Screening of Pancreatic Cancer.

Monitoring biomarkers offers insights for early disease (e.g., cancer, chronic diseases) screening, treatment guidance and response evaluation. To tackle challenges in precise biomarker detection in complex blood samples, we propose a metal-organic framework (MOF)-enhanced anti-fouling immunoprobe (MAIP). This sensing platform integrates several key features, including an anti-fouling surface, ful...

Jul 1 2025 40598854

AI-augmented differential diagnosis of granulomatous rosacea and lupus miliaris disseminatus faciei: A 23-year retrospective pilot study.

Granulomatous rosacea (GR) and lupus miliaris disseminatus faciei (LMDF) exhibit overlapping clinical features, making their differentiation challenging. While histopathological examination remains the gold standard, it is invasive and time-consuming, highlighting the need for non-invasive diagnostic approaches. This study evaluates artificial intelligence (AI)-based models for differentiating bet...

Jun 30 2025 40587564
Sex differences in serum proteomic profiles in psoriatic arthritis.

OBJECTIVES: Sex-related differences exist in the clinical presentation and treatment outcomes of patients with psoriatic arthritis (PsA). The biologic...

Jun 25 2025 40560578
The role of lubrication in function and degeneration of articular cartilage: A critical review and perspectives.

Articular cartilage is a porous, soft tissue present in the synovial joints that distributes the load and lubricate the joint for smooth body movement...

Jun 25 2025 40562049
Temporal Dynamics of APOE and TREM2 Expression in Microglial Activation of NMOSD Mouse Models.

Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune demyelinating disease characterized by recurrent neuroinflammation and disabilit...

Jun 23 2025 40549067
Real-world faricimab switch in France: artificial intelligence-based detection of changes in exudative signs in difficult-to-treat neovascular age-related macular degeneration.

PURPOSE: Some patients with neovascular age-related macular degeneration (nAMD) have persistent signs of exudation under treatment with intravitreal i...

Jun 23 2025 40550705
A New Insight in Cellular and Molecular Signaling Regulation for Neural Differentiation Program.

Numerous neurological conditions impact the brain, spinal cord, and nerves, including neurodegenerative diseases such as Alzheimer's and Parkinson's d...

Jun 20 2025 40540177
Microglial pruning of glycinergic synapses disinhibits spinal PKCγ interneurons to drive pain hypersensitivity in mice.

Microglial activation is linked to neuroinflammation in neuropathic pain. Recently, microglia-mediated synaptic pruning has received mounting attentio...

Jun 18 2025 40531965
Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication.

Bio-instructive materials that intrinsically inhibit biofilm formation have significant anti-biofouling potential in industrial and healthcare setting...

Jun 18 2025 40533450
An effective statistical moment-based feature extraction technique to identify the phosphoglycerylation sites from protein sequences.

A kind of covalent modification known as post-translational modification (PTM) happens following the biosynthesis process, which is important in cell ...

Jun 16 2025 40527193
Melioidosis molecular diagnostics: An update.

Melioidosis, a fatal tropical disease, presents a wide array of clinical manifestations, including abscesses, pneumonia, septic shock, bacteraemia, os...

Jun 14 2025 40515758
From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics.

The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened synaptogenesis, and the dynami...

Jun 14 2025 40516005
Discovery of Novel Anti-Acetylcholinesterase Peptides Using a Machine Learning and Molecular Docking Approach.

OBJECTIVE: Alzheimer's disease poses a significant threat to human health. Currenttherapeutic medicines, while alleviate symptoms, fail to reverse the...

Jun 14 2025 40534898
Global variations in artificial intelligence-generated information on juvenile idiopathic arthritis.

OBJECTIVES: We aimed to evaluate similarities and variations of information provided by Large Language Models (LLMs) across diverse world regions by a...

Jun 12 2025 40504018
Integrative exome sequencing and machine learning identify MICB and interferon pathway genes as contributors to SSc risk.

OBJECTIVES: Systemic sclerosis (SSc) is a complex autoimmune disease with both known and unidentified genetic contributors. While genome-wide associat...

Jun 12 2025 40514331
Identification of lipid metabolism-associated biomarkers in lupus nephritis by SVM model and therapeutic potential of Alisol B 23-acetate.

Systemic lupus erythematosus (SLE), a multifaceted autoimmune disorder, has lupus nephritis (LN) as one of its grave complications and is strongly ass...

Jun 10 2025 40505998
A high-throughput analysis of novel anti-fibrotics in human adult cardiac fibroblasts.

Myocardial fibrosis, a hallmark of heart failure (HF), contributes to disease progression and mortality by impairing cardiac function. Despite the ide...

Jun 3 2025 40466395
Integrative machine learning identifies robust inflammation-related diagnostic biomarkers and stratifies immune-heterogeneous subtypes in Kawasaki disease.

BACKGROUND: Kawasaki disease (KD), a pediatric systemic vasculitis, lacks reliable diagnostic biomarkers and exhibits immune heterogeneity, complicati...

Jun 2 2025 40457357
A Systematic Review of Clinical Trial Designs and Outcome Measures in Sjögren Disease Randomized Controlled Trials.

OBJECTIVE: To systematically review all existing Sjögren disease (SjD)-related instruments reported in clinical trials for SjD.

Jun 1 2025 40169213
Tumor-specific draining lymph node CD8 T cells orchestrate an anti-tumor response to neoadjuvant PD-1 immune checkpoint blockade.

Elucidating the anti-tumor role of tumor-draining lymph nodes (tdLNs) in patients could offer critical mechanistic insight and shift therapeutic strat...

Jun 1 2025 40501950
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