Latest AI and machine learning research in skin cancer for healthcare professionals.
The epidermal growth factor receptor (EGFR) is a key target in cancer therapy, mainly in non-small cell lung cancer (NSCLC). Though, the efficacy of EGFR-targeted therapies is limited by the development of resistance. This comprehensive review details the structural biology of EGFR and its role in oncogenic signaling, elucidating the major activating mutations, particularly exon 19 deletions and L...
The discovery of natural killer (NK) cells stands among the fundamental milestones in modern immunology. To mark the 50-year anniversary of the first publications on NK cells in 1975, a symposium was held at Karolinska Institutet in Stockholm, Sweden, on October 14, 2025. The symposium brought together scientists from across generations to reflect on the field's historical roots and future directi...
Recent advancements in cancer immunotherapy have transformed clinical oncology, with monoclonal antibodies (mAbs), immune checkpoint inhibitors, adopt...
Hepatocellular carcinoma (HCC) represents an extremely complex and heterogeneous malignant tumor. Protein palmitoylation, a highly conserved and pivot...
Ribonucleic acid (RNA) modifications, once viewed as static structural features, are now recognized as dynamic regulators of the 'epitranscriptome' th...
BACKGROUND: Uveal melanoma (UM) is a rare cancer with an estimated annual incidence of 6 incidences per million people. About half of UM patients deve...
Advancements in deep learning technologies and an increase in medical data have enhanced the accuracy of disease diagnosis and treatment strategies. N...
BACKGROUND: Hymenoptera venom immunotherapy is an established treatment for severe allergic reactions, aiming to modulate the immune response and redu...
In contrast to the MSI-H subtype, most microsatellite-stable (MSS) colorectal cancer (CRC) patients exhibit poor prognosis and limited responsiveness ...
Lung adenocarcinoma (LUAD) displays significant morphological and molecular heterogeneity both within and between tumors. This heterogeneity, coupled ...
Various exosome-derived proteins have been reported to play essential roles in regulating colorectal cancer progression and affecting the prognosis of...
Wearable microneedles (MNs) biosensors offer significant potential for minimally invasive biomarker detection in interstitial fluid (ISF). However, su...
Recent innovations in skin microphysiological systems (MPSs) have gained momentum following regulatory advances such as the FDA Modernization Act 2.0 ...
Aging and age-related diseases are a major public health concern, driving interest in anti-aging research. While small molecules and natural compounds...
Immunotherapy, a therapeutic strategy aimed at modulating the host immune system, has undergone rapid evolution over recent decades, particularly in o...
Mushrooms are rich in structurally diverse bioactive compounds that exert potent immunomodulatory effects, making them promising candidates for next-g...
Allostery, a crucial phenomenon for comprehending protein function, interactions, and regulation, involves the transmission of perturbations induced b...
The interplay between the commensal microbiota and the mammalian immune system may influence the outcomes of T cell-driven cancer immunotherapies. How...
In recent years, with the rapid development of medical device and biopharmaceutical technologies, the treatment model of gastric cancer surgery has be...
In the over-century-long history of colorectal tumor surgery, achieving organ function preservation has consistently been a central topic. Currently, ...