Transplantation

A Novel Approach for Handling Missing Data in Multivariate Time Series Clustering: Case Study on Predicting Delayed Graft Function.

Single value imputation and Multiple Imputation Chained Equation (MICE) are widely used for handling missing data cross-sectionally. Although several predictive and generative deep learning based methods address missing multivariate time series (MTS) data under Missing at Random /Missing Completely at Random types of missingness, their performance banks on the interpretation of missingness. Missin...

Human-AI Interaction in Kidney Transplant Decision Support Systems: Qualitative Study of Patient and Support Person Expectations.

BACKGROUND: Artificial intelligence (AI) is increasingly applied in medicine, including clinical decision-making. AI-based decision support systems (DSS) can enhance early risk detection and treatment optimization. However, the perspectives of patients and their support persons on AI-assisted DSS in clinical care, particularly regarding shared decision-making (SDM), remain underexplored. OBJECTIVE...

"Bioprinting of Hair: How Far We Proceeded and What Needs to be Done".

Alopecia is a common dermatologic disorder with psychological and quality-of-life impact. Current options such as PRP, topical agents, microneedling o...

Liquid Metal-Enabled Soft Bioelectronics for Human Health Monitoring.

Continuous, real-time, and accurate monitoring of human physiological signals is crucial for proactive healthcare and chronic disease management. Trad...

Fast reconstruction of degenerate populations of conductance-based neuron models from spike times.

Inferring the biophysical parameters of conductance-based models (CBMs) from experimentally accessible recordings remains a central challenge in compu...

Objective-function-guided automated VMAT planning reduces OAR dose, low-dose exposure, and inter-planner variability in breast radiotherapy.

This study presents and evaluates an automated volumetric modulated arc therapy (VMAT) planning framework for breast cancer based on objective functio...

Antibiotic therapy in febrile neutropenia in haematological patients: current considerations and future challenges.

The management of febrile neutropenia (FN) in oncohematological patients is undergoing a paradigm shift driven by a deeper understanding of patients' ...

ToxiGuard: an AOP-guided mechanistically interpretable framework for multi-organ toxicity prediction.

Accurate prediction of organ-specific toxicity with mechanistic interpretability remains a central challenge in chemical safety assessment and transla...

PFAS is associated with perineural invasion in triple-negative breast cancer with a potential role for Cathepsin D dysregulation: a multi-omics and experimental study.

Per- and polyfluoroalkyl substances (PFAS) are persistent pollutants linked to breast cancer (BC), but their role in perineural invasion (PNI) of trip...

Targeting tumor-associated G-protein coupled receptors: beyond single-axis inhibition toward multidimensional regulation.

G protein-coupled receptors (GPCRs) serve as central hubs in tumor signal transduction and microenvironment regulation. However, their therapeutic exp...

Alignment Between Cardiologists and AI-Driven Diagnostic Systems: Mixed Methods Study.

BACKGROUND: The clinical value of artificial intelligence (AI)-based diagnostic systems depends not only on their accuracy but also on how well their ...

Tuning the microenvironment of dual-atom catalysts for enhanced electrocatalysis: synthesis strategies, mechanistic insights, and future perspectives.

Dual-atom catalysts (DACs) have emerged as a transformative class of atomically dispersed catalysts that bridge the gap between single-atom catalysts ...

Artificial intelligence in the care of systemic lupus erythematosus: Current capabilities and translational barriers.

BackgroundThe clinical heterogeneity of systemic lupus erythematosus exceeds the resolution of conventional disease activity instruments. Artificial i...

A deep-learning framework reveals whole-body perturbations at cell level.

Many diseases, including obesity, have systemic effects that perturb multiple organ systems throughout the body1,2. However, tools for comprehensive, ...

Attention-Based Point Cloud Completion for CT-Equivalent Kidney Volumetry from Tracked Freehand Ultrasound.

Kidney volume measurement is critical for managing polycystic kidney disease and monitoring transplants, but computed tomography involves radiation an...

Genetic and immunological determinants of Pemphigus vulgaris: integrative analysis of HLA-DRB1 and FCGR2B variants.

Pemphigus vulgaris (PV) is a rare autoimmune blistering disease mediated by pathogenic autoantibodies. Although both HLA and non-HLA loci contribute t...

Prospects and Challenges of Personalized Immunotherapy in Breast Cancer Treatment and Long-term Cancer Management.

Breast cancer is highly heterogeneous,and different molecular subtypes exhibit significant variations in their response to immunotherapy.While signifi...

HELIX: a scalable model for predicting context-dependent regulation of RNA splicing and isoform usage.

Context-dependent alternative splicing plays a critical role in disease pathogenesis and organ development, but its complex regulation remains challen...

Bridging pediatric to adult care in cystinosis: a scoping review of healthcare transition of care protocols and a roadmap for future practice.

Cystinosis is a rare lysosomal storage disorder that affects approximately 1 in 100,000 to 200,000 live births worldwide. Long-term graft success in c...

From histology to spatial transcriptomics: establishing a lightweight single-patch baseline.

Predicting spatial gene expression from hematoxylin and eosin (H&E)-stained histological images is a central challenge in the field of computational p...