Proceedings of the National Academy of Sciences of the United States of America
Apr 18, 2025
Interdisciplinary research is essential for addressing complex global challenges, but there are concerns that scientific institutions like journals select against it. Prior work has focused largely on how interdisciplinarity relates to outcomes for p...
Proceedings of the National Academy of Sciences of the United States of America
Apr 17, 2025
There is broad consensus that AI presents risks, but considerable disagreement about the nature of those risks. These differing viewpoints can be understood as distinct narratives, each offering a specific interpretation of AI's potential dangers. On...
Proceedings of the National Academy of Sciences of the United States of America
Apr 8, 2025
Engineering small autonomous agents capable of operating in the microscale environment remains a key challenge, with current systems still evolving. Our study explores the fruit fly, , a classic model system in biology and a species adept at microsca...
Proceedings of the National Academy of Sciences of the United States of America
Apr 7, 2025
The study of bacterial metabolism holds immense significance for improving human health and advancing agricultural practices. The prospective applications of genomically encoded bacterial metabolism present a compelling opportunity, particularly in t...
Proceedings of the National Academy of Sciences of the United States of America
Mar 26, 2025
AI systems have attained superhuman performance across various domains. If the hidden knowledge encoded in these highly capable systems can be leveraged, human knowledge and performance can be advanced. Yet, this internal knowledge is difficult to ex...
Proceedings of the National Academy of Sciences of the United States of America
Mar 7, 2025
Neural circuits comprise multiple interconnected regions, each with complex dynamics. The interplay between local and global activity is thought to underlie computational flexibility, yet the structure of multiregion neural activity and its origins i...
Proceedings of the National Academy of Sciences of the United States of America
Mar 5, 2025
Despite the impressive performance of biological and artificial networks, an intuitive understanding of how their local learning dynamics contribute to network-level task solutions remains a challenge to this date. Efforts to bring learning to a more...
Proceedings of the National Academy of Sciences of the United States of America
Mar 4, 2025
Cardiomyocyte hypertrophy is a key clinical predictor of heart failure. High-throughput and AI-driven screens have the potential to identify drugs and downstream pathways that modulate cardiomyocyte hypertrophy. Here, we developed LogiRx, a logic-bas...
Proceedings of the National Academy of Sciences of the United States of America
Feb 26, 2025
Analyzing cardiac pulse waveforms offers valuable insights into heart health and cardiovascular disease risk, although obtaining the more informative measurements from the central aorta remains challenging due to their invasive nature and limited non...
Proceedings of the National Academy of Sciences of the United States of America
Feb 24, 2025
Brain age (BA), distinct from chronological age (CA), can be estimated from MRIs to evaluate neuroanatomic aging in cognitively normal (CN) individuals. BA, however, is a cross-sectional measure that summarizes cumulative neuroanatomic aging since bi...