AIMC Topic: Aged, 80 and over
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Global burden of vertebral fractures from 1990 to 2021 and projections for the next three decades.
Journal of orthopaedic surgery and research
May 17, 2025
BACKGROUND: Vertebral fractures are linked to significant disability and mortality risks. Yet, existing studies on their global burden are outdated and lack predictive foresight.
Brain metabolic imaging-based model identifies cognitive stability in prodromal Alzheimer's disease.
Scientific reports
May 17, 2025
The recent approval of anti-amyloid pharmaceuticals for the treatment of Alzheimer's disease (AD) has created a pressing need for the ability to accurately identify optimal candidates for anti-amyloid therapy, specifically those with evidence for inc...
Heterogeneous associations between early-life religious upbringing and late-life health: Evidence from a machine learning approach.
Social science & medicine (1982)
May 16, 2025
Religious upbringing was common in Europe during the childhood of older adults today. However, studies are still lacking on how early-life religious upbringing is associated with adult health and how this association differs in different population s...
Splenic and portal venous flow associated with frailty and sarcopenia in older outpatients with cardiovascular disease.
BMC geriatrics
May 9, 2025
BACKGROUND: Older patients with cardiovascular disease often experience frailty and sarcopenia. We evaluated whether a reduced blood flow in the splenic and portal vein is associated with frailty and sarcopenia in older patients with cardiovascular d...
Water intake, hydration status and cognitive functions in older adults - a pilot study.
European journal of nutrition
May 9, 2025
PURPOSE: This study aimed to assess the relationship between the hydration status and cognitive functioning of older adults. The novelty of the study was the simultaneous use of several indicators of hydration status, including plasma and urine osmol...
Improving lower-extremity artery depiction and diagnostic confidence using dual-energy technique and popliteal artery monitoring in dual-low dose CT angiography.
Scientific reports
May 9, 2025
To assess the utility of dual-energy CT scanning (DECTs) with popliteal artery (PA) monitoring in dual low-dose (radiation and contrast) lower-extremity CT angiography (LE-CTA). 135 patients undergoing LE-CTA were prospectively included and divided i...
Physiological comparison of noninvasive ventilation and high-flow nasal oxygen on inspiratory efforts and tidal volumes after extubation: a randomized crossover trial.
Critical care (London, England)
May 8, 2025
BACKGROUND: Extubation failure leading to reintubation is associated with high mortality. In patients at high-risk of extubation failure, clinical practice guidelines recommend prophylactic non-invasive ventilation (NIV) over high-flow nasal oxygen (...
Annotation-Free Whole-Slide Image Analysis Method to Assess Immune Infiltration in Colorectal Cancer.
JCO precision oncology
May 7, 2025
PURPOSE: Tumor-infiltrating lymphocytes (TILs) play a crucial role in host antitumor processes. High level of TILs is associated with better outcomes for patients. We aim to automatically quantify TILs without any nuclei annotation and further constr...
AgeML: Age Modeling With Machine Learning.
IEEE journal of biomedical and health informatics
May 6, 2025
An approach to age modeling involves the supervised prediction of age using machine learning from subject features. The derived age metrics are used to study the relationship between healthy and pathological aging in multiple body systems, as well as...
Optimizing elderly care: A data-driven AI model for predicting polypharmacy risk in the elderly using SHARE data.
Neuroscience
May 5, 2025
BACKGROUND: Aging is frequently accompanied by multimorbidity, the presence of multiple chronic conditions, which contributes to declines in both cognitive and physical function and presents complex health challenges. One such challenge is Polypharma...
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