AIMC Topic: Alzheimer Disease

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Use of Artificial Intelligence in Imaging Dementia.

Cells
Alzheimer's disease is the most common cause of dementia in the elderly population (aged 65 years and over), followed by vascular dementia, Lewy body dementia, and rare types of neurodegenerative diseases, including frontotemporal dementia. There is ...

BPEN: Brain Posterior Evidential Network for trustworthy brain imaging analysis.

Neural networks : the official journal of the International Neural Network Society
The application of deep learning techniques to analyze brain functional magnetic resonance imaging (fMRI) data has led to significant advancements in identifying prospective biomarkers associated with various clinical phenotypes and neurological cond...

Effective Alzheimer's disease detection using enhanced Xception blending with snapshot ensemble.

Scientific reports
Alzheimer's disease (AD), a prevalent neurodegenerative disorder, leads to progressive dementia, which impairs decision-making, problem-solving, and communication. While there is no cure, early detection can facilitate treatments to slow its progress...

Deep-learning assessment of hippocampal magnetic susceptibility in Alzheimer's disease.

Journal of Alzheimer's disease : JAD
BACKGROUND: Quantitative susceptibility mapping (QSM) is pivotal for analyzing neurodegenerative diseases. However, accurate hippocampal segmentation remains a challenge.

Identification and cognitive function prediction of Alzheimer's disease based on multivariate pattern analysis of hippocampal volumes.

Journal of Alzheimer's disease : JAD
BACKGROUND: Alzheimer's disease (AD) is strongly associated with slowly progressive hippocampal atrophy. Elucidating the relationships between local morphometric changes and disease status for early diagnosis could be aided by machine learning algori...

Graph Convolutional Network for AD and MCI Diagnosis Utilizing Peripheral DNA Methylation: Réseau de neurones en graphes pour le diagnostic de la MA et du TCL à l'aide de la méthylation de l'ADN périphérique.

Canadian journal of psychiatry. Revue canadienne de psychiatrie
OBJECTIVE: Blood DNA methylation (DNAm) alterations have been widely reported in the onset and progression of mild cognitive impairment (MCI) and Alzheimer's disease (AD); however, DNAm is underutilized as a diagnostic biomarker for these diseases. W...

Machine learning based on event-related oscillations of working memory differentiates between preclinical Alzheimer's disease and normal aging.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
OBJECTIVE: To apply machine learning approaches on EEG event-related oscillations (ERO) to discriminate preclinical Alzheimer's disease (AD) from age- and sex-matched controls.

Multi-scale multimodal deep learning framework for Alzheimer's disease diagnosis.

Computers in biology and medicine
Multimodal neuroimaging data, including magnetic resonance imaging (MRI) and positron emission tomography (PET), provides complementary information about the brain that can aid in Alzheimer's disease (AD) diagnosis. However, most existing deep learni...

Multiclass classification of Alzheimer's disease prodromal stages using sequential feature embeddings and regularized multikernel support vector machine.

NeuroImage
The detection of patients in the cognitive normal (CN), mild cognitive impairment (MCI), and Alzheimer's disease (AD) stages of neurodegeneration is crucial for early treatment interventions. However, the heterogeneity of MCI data samples poses a cha...

A Transcriptomics-Based Machine Learning Model Discriminating Mild Cognitive Impairment and the Prediction of Conversion to Alzheimer's Disease.

Cells
The clinical spectrum of Alzheimer's disease (AD) ranges dynamically from asymptomatic and mild cognitive impairment (MCI) to mild, moderate, or severe AD. Although a few disease-modifying treatments, such as lecanemab and donanemab, have been develo...