AIMC Topic: Animals

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Development and application of cell-based bioassay in aquatic toxicity assessment.

Aquatic toxicology (Amsterdam, Netherlands) May 26, 2025
Cell-based bioassays provide a dynamic and physiologically relevant platform for investigating cellular responses to chemical, biological, and environmental stimuli. Unlike traditional biochemical assays, cell-based bioassays utilize living cells to ...
Toxicity Tests Animals Water Pollutants, Chemical Biological Assay
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Mechanistic exploration of hexokinase 2 and metabolism in diabetic cardiomyopathy.

Molecular medicine reports May 26, 2025
The pathogenesis of diabetic cardiomyopathy (DCM) remains incompletely understood. The present study employed weighted gene co‑expression network analysis to analyze the DCM transcriptome dataset from the Gene Expression Omnibus (GEO) database to ide...
Male Gene Expression Profiling Diabetic Cardiomyopathies Hexokinase Disease Models, Animal Humans Transcriptome Animals Mice
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Easy and Fast Discrimination of Female Sand Flies from Species with Infrared Spectroscopy and Multivariate Analysis.

Analytical chemistry May 26, 2025
Accurate identification of sandfly species is critical for controlling and preventing the spread of visceral leishmaniasis, a major public health concern in Latin America. Morphological similarities between female and present a significant challeng...
Female Animals Machine Learning Principal Component Analysis Multivariate Analysis Support Vector Machine Spectroscopy, Fourier Transform Infrared Psychodidae
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Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability.

Journal of nanobiotechnology May 26, 2025
The blood-brain barrier (BBB) represents a formidable challenge in the treatment of neurological disorders, as it restricts the passage of most therapeutic agents into the central nervous system (CNS). Research in brain-targeted delivery strategies a...
Drug Delivery Systems Animals Biological Products Permeability Brain Humans Blood-Brain Barrier
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Volumetric atlas of the rat inner ear from microCT and iDISCO+ cleared temporal bones.

PeerJ May 26, 2025
BACKGROUND: Volumetric atlases are an invaluable tool in neuroscience and otolaryngology, greatly aiding experiment planning and surgical interventions, as well as the interpretation of experimental and clinical data. The rat is a major animal model ...
Temporal Bone X-Ray Microtomography Atlases as Topic Rats Ear, Inner Animals
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Prediction of reproductive and developmental toxicity using an attention and gate augmented graph convolutional network.

Scientific reports May 25, 2025
Due to the diverse molecular structures of chemical compounds and their intricate biological pathways of toxicity, predicting their reproductive and developmental toxicity remains a challenge. Traditional Quantitative Structure-Activity Relationship ...
Neural Networks, Computer Computer Simulation Animals Deep Learning Humans Reproduction Quantitative Structure-Activity Relationship
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A novel feature fusion and mountain gazelle optimizer based framework for the recognition of jute pests in sustainable agriculture.

Scientific reports May 25, 2025
Sustainable agriculture is an approach that involves adopting and developing agricultural practices to increase efficiency and preserve resources, both environmentally and economically. Jute is one of the primary sources of income grown in many count...
Animals Artificial Intelligence Agriculture Crops, Agricultural Algorithms
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Extrachromosomal circular DNA drives dynamic genome plasticity: emerging roles in disease progression and clinical potential.

Theranostics May 25, 2025
Extrachromosomal circular DNA (eccDNA) has emerged as a dynamic and versatile genomic element with key roles in physiological regulation and disease pathology. This review synthesizes current knowledge on eccDNA, covering its classification, biogenes...
DNA, Circular Disease Progression DNA Repair Animals Neoplasms Humans
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Unique bioaccumulation and biosynthesis of arsenobetaine in marine fish.

Aquatic toxicology (Amsterdam, Netherlands) May 24, 2025
Arsenic (As) contamination represents a significant global concern, particularly prevalent in regions such as China, South Asia, and Southeast Asia. Arsenic permeates the food chain, posing potential hazards to ecosystems and human health. Studies ha...
Arsenicals Fishes Animals Bioaccumulation Water Pollutants, Chemical Food Chain
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Novel Computational Approaches in the Discovery and Identification of Bioactive Peptides: A Bioinformatics Perspective.

Journal of agricultural and food chemistry May 24, 2025
Bioactive peptides are protein molecules known for their specific biological functions, offering promising applications across various fields including medicine, food, and cosmetics. Traditional approaches to the investigation of bioactive peptides t...
Humans Peptides Quantitative Structure-Activity Relationship Computational Biology Computer Simulation Machine Learning Animals
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