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Anti-Bacterial Agents

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What are the most relevant publications in Clinical Microbiology in the last two years?

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia
This minireview describes some of the articles published in the last two years related to innovative technologies including CRISPR-Cas, surface-enhanced Raman spectroscopy, microfluidics, flow cytometry, Fourier transform infrared spectroscopy, and a...

Antibiotics, Sedatives, and Catecholamines Further Compromise Sepsis-Induced Immune Suppression in Peripheral Blood Mononuclear Cells.

Critical care medicine
OBJECTIVES: We hypothesized that the immunosuppressive effects associated with antibiotics, sedatives, and catecholamines amplify sepsis-associated immune suppression through mitochondrial dysfunction, and there is a cumulative effect when used in co...

Deep learning and single-cell phenotyping for rapid antimicrobial susceptibility detection in Escherichia coli.

Communications biology
The rise of antimicrobial resistance (AMR) is one of the greatest public health challenges, already causing up to 1.2 million deaths annually and rising. Current culture-based turnaround times for bacterial identification in clinical samples and anti...

Identifying ARG-carrying bacteriophages in a lake replenished by reclaimed water using deep learning techniques.

Water research
As important mobile genetic elements, phages support the spread of antibiotic resistance genes (ARGs). Previous analyses of metaviromes or metagenome-assembled genomes (MAGs) failed to assess the extent of ARGs transferred by phages, particularly in ...

Methyl cellulose/okra mucilage composite films, functionalized with Hypericum perforatum oil and gentamicin, as a potential wound dressing.

International journal of biological macromolecules
There is a growing demand for the development of functional wound dressings enriched with bioactive natural compounds to improve the quality of life of the population by accelerating the healing process of chronic wounds. In this regard, a functional...

Deep learning tools to accelerate antibiotic discovery.

Expert opinion on drug discovery
INTRODUCTION: As machine learning (ML) and artificial intelligence (AI) expand to many segments of our society, they are increasingly being used for drug discovery. Recent deep learning models offer an efficient way to explore high-dimensional data a...

Beyond SEP-1 Compliance: Assessing the Impact of Antibiotic Overtreatment and Fluid Overload in Suspected Septic Patients.

The Journal of emergency medicine
BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) developed the Severe Sepsis and Septic Shock Performance Measure bundle (SEP-1) metric to improve sepsis care, but evidence supporting this bundle is limited and harms secondary to comp...

Artificial intelligence-accelerated high-throughput screening of antibiotic combinations on a microfluidic combinatorial droplet system.

Lab on a chip
Microfluidic platforms have been employed as an effective tool for drug screening and exhibit the advantages of lower reagent consumption, higher throughput and a higher degree of automation. Despite the great advancement, it remains challenging to s...

Recent Advances of Biosensors for Detection of Multiple Antibiotics.

Biosensors
The abuse of antibiotics has caused a serious threat to human life and health. It is urgent to develop sensors that can detect multiple antibiotics quickly and efficiently. Biosensors are widely used in the field of antibiotic detection because of th...

Photothermal Conversion of Hydrogel-Based Biomaterial.

Chemical record (New York, N.Y.)
Traditional energy from fossil fuels like petroleum and coal is limited and contributes to global environmental pollution and climate change. Developing sustainable and eco-friendly energy is crucial for addressing significant challenges such as clim...