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Anti-Infective Agents

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Antimicrobial Activity of Extract Used for Potential Application in the Prevention and Treatment of Oral Diseases.

Medicina (Kaunas, Lithuania)
: This study evaluated the antimicrobial effect and cytotoxic potential of the natural extract against (), the causative agent of dental caries, which is a typical oral disease, and (), which causes oral candidiasis. : was shaken in 70% ethanol f...

Main-Chain Sulfonium-Containing Homopolymers with Negligible Hemolytic Toxicity for Eradication of Bacterial and Fungal Biofilms.

ACS macro letters
Antimicrobials against planktonic cells and established biofilms at low doses are in increasing demand to tackle antibiotic-resistant biofilm infections. As a promising alternative to antibiotics, cationic polymers can effectively kill planktonic mic...

Artificial intelligence as a smart approach to develop antimicrobial drug molecules: A paradigm to combat drug-resistant infections.

Drug discovery today
Antimicrobial resistance (AMR) is a silent pandemic with the third highest global mortality. The antibiotic development pipeline is scarce even though AMR has escalated uncontrollably. Artificial intelligence (AI) is a revolutionary approach, acceler...

Leveraging artificial intelligence in the fight against infectious diseases.

Science (New York, N.Y.)
Despite advances in molecular biology, genetics, computation, and medicinal chemistry, infectious disease remains an ominous threat to public health. Addressing the challenges posed by pathogen outbreaks, pandemics, and antimicrobial resistance will ...

Antimicrobial treatment imprecision: an outcome-based model to close the data-to-action loop.

The Lancet. Infectious diseases
Health-care systems, food supply chains, and society in general are threatened by the inexorable rise of antimicrobial resistance. This threat is driven by many factors, one of which is inappropriate antimicrobial treatment. The ability of policy mak...

Using chronobiology-based second-generation artificial intelligence digital system for overcoming antimicrobial drug resistance in chronic infections.

Annals of medicine
Antimicrobial resistance results from the widespread use of antimicrobial agents and is a significant obstacle to the effectiveness of these agents. Numerous methods are used to overcome this problem with moderate success. Besides efforts of antimicr...

Novel antimicrobial peptides against Cutibacterium acnes designed by deep learning.

Scientific reports
The increasing prevalence of antibiotic resistance in Cutibacterium acnes (C. acnes) requires the search for alternative therapeutic strategies. Antimicrobial peptides (AMPs) offer a promising avenue for the development of new treatments targeting C....

Explainable and Interpretable Machine Learning for Antimicrobial Stewardship: Opportunities and Challenges.

Clinical therapeutics
There is growing interest in exploiting the advances in artificial intelligence and machine learning (ML) for improving and monitoring antimicrobial prescriptions in line with antimicrobial stewardship principles. Against this background, the concept...