AIMC Topic: Antibodies, Monoclonal, Humanized

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Predicting Secukinumab Fast-Responder Profile in Psoriatic Patients: Advanced Application of Artificial-Neural-Networks (ANNs).

Journal of drugs in dermatology : JDD Dec 1, 2020
BACKGROUND: Drug resistance to biologics in psoriasis therapy can occur – it may be acquired during a treatment or else present itself from the beginning. To date, no biomarkers are known that may reliably guide clinicians in predicting respons...
Pilot Projects Time Factors Injections, Subcutaneous Middle Aged Severity of Illness Index Deep Learning Biological Products Predictive Value of Tests Drug Resistance Models, Immunological Prospective Studies Treatment Outcome Biomarkers Antibodies, Monoclonal, Humanized Prognosis Psoriasis Female Adult Male Humans
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Application of machine intelligence technology in the detection of vaccines and medicines for SARS-CoV-2.

European review for medical and pharmacological sciences Nov 1, 2020
Researchers have found many similarities between the 2003 severe acute respiratory syndrome (SARS) virus and SARS-CoV-19 through existing data that reveal the SARS's cause. Artificial intelligence (AI) learning models can be created to predict drug s...
Drug Development Antibodies, Monoclonal, Humanized Drug Combinations Deep Learning Antiviral Agents COVID-19 Vaccines Ascorbic Acid Ritonavir COVID-19 Drug Treatment Ribavirin Immunosuppressive Agents Drug Repositioning Vitamins Humans Artificial Intelligence Machine Learning COVID-19 Hydroxychloroquine Adenosine Monophosphate Alanine Lopinavir Chloroquine
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The Association Between Arthralgia and Vedolizumab Using Natural Language Processing.

Inflammatory bowel diseases Sep 15, 2018
BACKGROUND: The gut-selective nature of vedolizumab has raised questions regarding increased joint pain or arthralgia with its use in inflammatory bowel disease (IBD) patients. As arthralgias are seldom coded and thus difficult to study, few studies ...
Gastrointestinal Agents Arthralgia Follow-Up Studies Immunosuppressive Agents Natural Language Processing Adult Male Antibodies, Monoclonal, Humanized Humans Tumor Necrosis Factor-alpha Prognosis Electronic Health Records Female Inflammatory Bowel Diseases Retrospective Studies
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Predicting Corticosteroid-Free Biologic Remission with Vedolizumab in Crohn's Disease.

Inflammatory bowel diseases May 18, 2018
BACKGROUND AND AIMS: Vedolizumab (VDZ) is effective for Crohn's disease (CD) but costly and is slow to produce remission. Early knowledge of whether vedolizumab is likely to succeed is valuable for physicians, patients, and insurers.
Middle Aged Cohort Studies ROC Curve Treatment Outcome Antibodies, Monoclonal, Humanized Biological Products Young Adult Adult Male Humans Machine Learning Female C-Reactive Protein Area Under Curve Crohn Disease Gastrointestinal Agents Remission Induction Adrenal Cortex Hormones
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Efficacy of eculizumab in an adult patient with HIV-associated hemolytic uremic syndrome: A case report.

Medicine Dec 1, 2017
INTRODUCTION: Hemolytic uremic syndrome (HUS) in Human Immunodeficiency Virus (HIV)-positive patients has become a rare cause of kidney injury since the era of highly active antiretroviral therapy (HAART). Plasma exchange and antiretroviral therapy w...
Hemolytic-Uremic Syndrome HIV Infections Plasma Exchange Treatment Outcome Antibodies, Monoclonal, Humanized Middle Aged Kidney Function Tests Humans Antiretroviral Therapy, Highly Active Risk Assessment Follow-Up Studies Acute Kidney Injury Renal Dialysis Immunohistochemistry Antibodies, Monoclonal Female Biopsy, Needle
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VH-VL orientation prediction for antibody humanization candidate selection: A case study.

mAbs Jan 1, 2016
Antibody humanization describes the procedure of grafting a non-human antibody's complementarity-determining regions, i.e., the variable loop regions that mediate specific interactions with the antigen, onto a β-sheet framework that is representative...
Humans Protein Structure, Secondary Complementarity Determining Regions Machine Learning Structural Homology, Protein Antibodies, Monoclonal, Humanized Models, Molecular
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