AIMC Topic: beta-Thalassemia
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Detection of β-Thalassemia trait from a heterogeneous population with red cell indices and parameters.
Computers in biology and medicine
Apr 26, 2025
BACKGROUND: India is home to about 42 million people with β-thalassemia trait (βTT) necessitating screening of βTT to stop spread of the disease. Over the years, researchers developed discrimination formulae based on red blood cell (RBC) parameters t...
A comprehensive case study of deep learning on the detection of alpha thalassemia and beta thalassemia using public and private datasets.
Scientific reports
Apr 17, 2025
This study explores the performance of deep learning models, specifically Convolutional Neural Networks (CNN) and XGBoost, in predicting alpha and beta thalassemia using both public and private datasets. Thalassemia is a genetic disorder that impairs...
Convolutional neural networks for automatic MR classification of myocardial iron overload in thalassemia major patients.
European radiology
Dec 10, 2024
OBJECTIVES: To develop a deep-learning model for supervised classification of myocardial iron overload (MIO) from magnitude T2* multi-echo MR images.
Support Vector Machine-Based Formula for Detecting Suspected α Thalassemia Carriers: A Path toward Universal Screening.
International journal of molecular sciences
Jun 11, 2024
The blood counts of α thalassemia carriers (α-thal) are similar to those of β thalassemia carriers, except for Hemoglobin A (Hb A), which is not elevated. The objective of this study was to determine whether mathematical formulas are effective for de...
MRI Deep Learning-Based Automatic Segmentation of Interventricular Septum for Black-Blood Myocardial T2* Measurement in Thalassemia.
Journal of magnetic resonance imaging : JMRI
Nov 9, 2023
BACKGROUND: The T2* value of interventricular septum is routinely reported for grading myocardial iron load in thalassemia major, and automatic segmentation of septum could shorten analysis time and reduce interobserver variability.
Profiling of 35 Cases of Hb S/Hb E (: c.20A>T/: c.79G>a), Disease and Association with α-Thalassemia and β-Globin Gene Cluster Haplotypes from Odisha, India.
Hemoglobin
Mar 4, 2022
Hb S/Hb E (: c.20A>T/: c.79G>A) is an uncommon variant of sickle cell disease resulting from coinheritance of Hb S and Hb E. Clinico-hematological and biochemical parameters of 35 cases of Hb S/Hb E disease were studied and compared with 70 matched c...
Evaluation of the Association of Transferrin Receptor Type 2 Gene Mutation (Y250X) with Iron Overload in Major β- Thalassemia.
Archives of Razi Institute
Nov 30, 2021
Thalassemia is an inherited blood disorder in which the body produces defective hemoglobin. One of the important processes to reduce the complication of major β-thalassemia is blood transfusion that leads to elevated ferritin levels in the blood. Man...
An automated liver segmentation in liver iron concentration map using fuzzy c-means clustering combined with anatomical landmark data.
BMC medical imaging
Sep 28, 2021
BACKGROUND: To estimate median liver iron concentration (LIC) calculated from magnetic resonance imaging, excluded vessels of the liver parenchyma region were defined manually. Previous works proposed the automated method for excluding vessels from t...
Conformational changes of β-thalassemia major hemoglobin and oxidative status of plasma after in vitro exposure to extremely low-frequency electromagnetic fields: An artificial neural network analysis.
Electromagnetic biology and medicine
Oct 23, 2020
Electromagnetic fields (EMF) can generate reactive oxygen species and induce oxidative modifications. We investigated the effects of extremely low-frequency electromagnetic fields (ELF-EMF) on oxidative status of plasma and erythrocytes in β-thalasse...
ThalPred: a web-based prediction tool for discriminating thalassemia trait and iron deficiency anemia.
BMC medical informatics and decision making
Nov 7, 2019
BACKGROUND: The hypochromic microcytic anemia (HMA) commonly found in Thailand are iron deficiency anemia (IDA) and thalassemia trait (TT). Accurate discrimination between IDA and TT is an important issue and better methods are urgently needed. Altho...
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