AIMC Topic: Biofilms

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Bow-tie signaling in c-di-GMP: Machine learning in a simple biochemical network.

PLoS computational biology
Bacteria of many species rely on a simple molecule, the intracellular secondary messenger c-di-GMP (Bis-(3'-5')-cyclic dimeric guanosine monophosphate), to make a vital choice: whether to stay in one place and form a biofilm, or to leave it in search...

Simulating the fate of indigenous antibiotic resistant bacteria in a mild slope wastewater polluted stream.

Journal of environmental sciences (China)
The fate of indigenous surface-water and wastewater antibiotic resistant bacteria in a mild slope stream simulated through a hydraulic channel was investigated in outdoor experiments. The effect of (i) natural (dark) decay, (ii) sunlight, (iii) cloud...

Pathogen biofilm formation on cantaloupe surface and its impact on the antibacterial effect of lauroyl arginate ethyl.

Food microbiology
Pathogen biofilm at fruit surface may pose a particular risk to food safety. In this study, the biofilms of Listeria monocytogenes V7 and Salmonella enterica serovar Typhimurium ATCC 13311 on cantaloupe fruit surface were visualized, and the resistan...

Adherence of staphylococcus aureus to catheter tubing inhibition by quaternary ammonium compounds.

The Pan African medical journal
INTRODUCTION: is a Gram positive bacterium which is responsible for a wide range of infections. This pathogen has also the ability to adhere to biotic or abiotic surface such as central venous catheter (CVC) and to produce a biofilm. The aim of this...

New Derivatives of Pyridoxine Exhibit High Antibacterial Activity against Biofilm-Embedded Staphylococcus Cells.

BioMed research international
Opportunistic bacteria Staphylococcus aureus and Staphylococcus epidermidis often form rigid biofilms on tissues and inorganic surfaces. In the biofilm bacterial cells are embedded in a self-produced polysaccharide matrix and thereby are inaccessible...

Antimicrobial peptide developed with machine learning sequence optimization targets drug resistant Staphylococcus aureus in mice.

The Journal of clinical investigation
As antimicrobial resistance rises, new antibacterial candidates are urgently needed. Using sequence space information from over 14,743 functional antimicrobial peptides (AMPs), we improved the antimicrobial properties of citropin 1.1, an AMP with wea...

Analysis of biofilm assembly by large area automated AFM.

NPJ biofilms and microbiomes
Biofilms are complex microbial communities critical in medical, industrial, and environmental contexts. Understanding their assembly, structure, genetic regulation, interspecies interactions, and environmental responses is key to developing effective...

Deep learning revealed the distribution and evolution patterns for invertible promoters across bacterial lineages.

Nucleic acids research
Invertible promoters (invertons) are crucial regulatory elements in bacteria, facilitating gene expression changes under stress. Despite their importance, their prevalence and the range of regulated gene functions are largely unknown. We introduced D...

Comprehensive assessment of machine learning-based methods for predicting antimicrobial peptides.

Briefings in bioinformatics
Antimicrobial peptides (AMPs) are a unique and diverse group of molecules that play a crucial role in a myriad of biological processes and cellular functions. AMP-related studies have become increasingly popular in recent years due to antimicrobial r...

Evaluation of a protocol for reducing the microbial contamination of dental unit water.

Acta odontologica latinoamericana : AOL
Biofilm on dental unit waterlines can spread microbial contamination in the water. The aim of this study was to investigate microbial contamination of water from supplies and dental units before and after the implementation of a protocol for microbia...