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Breast Neoplasms

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Characterizing Sentinel Lymph Node Status in Breast Cancer Patients Using a Deep-Learning Model Compared With Radiologists' Analysis of Grayscale Ultrasound and Lymphosonography.

Ultrasound quarterly
The objective of the study was to use a deep learning model to differentiate between benign and malignant sentinel lymph nodes (SLNs) in patients with breast cancer compared to radiologists' assessments.Seventy-nine women with breast cancer were enro...

Glycosylphosphatidylinositol anchor biosynthesis pathway-based biomarker identification with machine learning for prognosis and T cell exhaustion status prediction in breast cancer.

Frontiers in immunology
As the primary component of anti-tumor immunity, T cells are prone to exhaustion and dysfunction in the tumor microenvironment (TME). A thorough understanding of T cell exhaustion (TEX) in the TME is crucial for effectively addressing TEX in clinical...

A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns.

Nature nanotechnology
The clustering of death receptors (DRs) at the membrane leads to apoptosis. With the goal of treating tumours, multivalent molecular tools that initiate this mechanism have been developed. However, DRs are also ubiquitously expressed in healthy tissu...

Factors influencing psychological distress among breast cancer survivors using machine learning techniques.

Scientific reports
Breast cancer is the most commonly diagnosed cancer among women worldwide. Breast cancer patients experience significant distress relating to their diagnosis and treatment. Managing this distress is critical for improving the lifespan and quality of ...

Advancing equity in breast cancer care: natural language processing for analysing treatment outcomes in under-represented populations.

BMJ health & care informatics
OBJECTIVE: The study aimed to develop natural language processing (NLP) algorithms to automate extracting patient-centred breast cancer treatment outcomes from clinical notes in electronic health records (EHRs), particularly for women from under-repr...

Weakly Supervised Lesion Detection and Diagnosis for Breast Cancers With Partially Annotated Ultrasound Images.

IEEE transactions on medical imaging
Deep learning (DL) has proven highly effective for ultrasound-based computer-aided diagnosis (CAD) of breast cancers. In an automatic CAD system, lesion detection is critical for the following diagnosis. However, existing DL-based methods generally r...

Clinical implementation of artificial-intelligence-assisted detection of breast cancer metastases in sentinel lymph nodes: the CONFIDENT-B single-center, non-randomized clinical trial.

Nature cancer
Pathologists' assessment of sentinel lymph nodes (SNs) for breast cancer (BC) metastases is a treatment-guiding yet labor-intensive and costly task because of the performance of immunohistochemistry (IHC) in morphologically negative cases. This non-r...

Deep Learning for Describing Breast Ultrasound Images with BI-RADS Terms.

Journal of imaging informatics in medicine
Breast cancer is the most common cancer in women. Ultrasound is one of the most used techniques for diagnosis, but an expert in the field is necessary to interpret the test. Computer-aided diagnosis (CAD) systems aim to help physicians during this pr...

Molecular Classification of Breast Cancer Using Weakly Supervised Learning.

Cancer research and treatment
PURPOSE: The molecular classification of breast cancer is crucial for effective treatment. The emergence of digital pathology has ushered in a new era in which weakly supervised learning leveraging whole-slide images has gained prominence in developi...