AIMC Topic: Cerebral Cortex

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Predictive learning rules generate a cortical-like replay of probabilistic sensory experiences.

eLife Jun 16, 2025
The brain is thought to construct an optimal internal model representing the probabilistic structure of the environment accurately. Evidence suggests that spontaneous brain activity gives such a model by cycling through activity patterns evoked by pr...
Nerve Net Macaca mulatta Action Potentials Neurons Cerebral Cortex Learning Animals Models, Neurological
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Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex.

Nature neuroscience Jun 6, 2025
From visual perception to language, sensory stimuli change their meaning depending on previous experience. Recurrent neural dynamics can interpret stimuli based on externally cued context, but it is unknown whether they can compute and employ interna...
Models, Neurological Mice, Inbred C57BL Neurons Animals Male Mice Space Perception Cerebral Cortex Gyrus Cinguli Photic Stimulation Neural Networks, Computer
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Evaluating methods for the prediction of cell-type-specific enhancers in the mammalian cortex.

Cell genomics May 21, 2025
Identifying cell-type-specific enhancers is critical for developing genetic tools to study the mammalian brain. We organized the "Brain Initiative Cell Census Network (BICCN) Challenge: Predicting Functional Cell Type-Specific Enhancers from Cross-Sp...
Computational Biology Cerebral Cortex Enhancer Elements, Genetic Machine Learning Chromatin Animals Dependovirus Mice
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Cortical-subcortical neural networks for motor learning and storing sequence memory.

Neural networks : the official journal of the International Neural Network Society May 7, 2025
Motor sequence learning relies on the synergistic collaboration of multiple brain regions. However, most existing models for motor sequence learning primarily focus on functional-level analyses of sequence memory mechanisms, providing limited neuroph...
Nerve Net Memory Thalamus Learning Humans Prefrontal Cortex Models, Neurological Memory, Short-Term Cerebral Cortex Neural Networks, Computer Neurons Neural Pathways
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Intersecting impact of CAG repeat and huntingtin knockout in stem cell-derived cortical neurons.

Neurobiology of disease Apr 19, 2025
Huntington's Disease (HD) is caused by a CAG repeat expansion in the gene encoding huntingtin (HTT). While normal HTT function appears impacted by the mutation, the specific pathways unique to CAG repeat expansion versus loss of normal function are u...
Humans Gene Knockout Techniques Huntington Disease Huntingtin Protein Trinucleotide Repeat Expansion Cell Differentiation Neurons Cerebral Cortex
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Neural models for detection and classification of brain states and transitions.

Communications biology Apr 11, 2025
Exploring natural or pharmacologically induced brain dynamics, such as sleep, wakefulness, or anesthesia, provides rich functional models for studying brain states. These models allow detailed examination of unique spatiotemporal neural activity patt...
Neural Networks, Computer Cerebral Cortex Models, Neurological Algorithms Animals Wakefulness Brain Sleep Male Rats
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The impact of Alzheimer's disease on cortical complexity and its underlying biological mechanisms.

Brain research bulletin Apr 4, 2025
BACKGROUND: Alzheimer's disease (AD) might impact the complexity of cerebral cortex, and the underlying biological mechanisms responsible for cortical changes in the AD cortex remain unclear.
Humans Machine Learning Alzheimer Disease Male Cerebral Cortex Female Middle Aged Atrophy Aged Magnetic Resonance Imaging Aged, 80 and over
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Understanding the Spatio-Temporal Coupling of Spikes and Spindles in Focal Epilepsy Through a Network-Level Computational Model.

International journal of neural systems Mar 15, 2025
The electrophysiological findings have shown that epileptiform spikes triggering sleep spindles within 1[Formula: see text]s across multiple channels are commonly observed during sleep in focal epilepsy (FE). Such spatio-temporal couplings of spikes ...
Nerve Net Thalamus Epilepsies, Partial Electroencephalography Cerebral Cortex Computer Simulation Brain Waves Models, Neurological Humans Action Potentials Neural Networks, Computer
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Sparse connectivity enables efficient information processing in cortex-like artificial neural networks.

Frontiers in neural circuits Mar 13, 2025
Neurons in cortical networks are very sparsely connected; even neurons whose axons and dendrites overlap are highly unlikely to form a synaptic connection. What is the relevance of such sparse connectivity for a network's function? Surprisingly, it h...
Neural Pathways Models, Neurological Humans Nerve Net Neurons Neural Networks, Computer Cerebral Cortex Animals
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Graph-based prototype inverse-projection for identifying cortical sulcal pattern abnormalities in congenital heart disease.

Medical image analysis Feb 28, 2025
Examining the altered arrangement and patterning of sulcal folds offers insights into the mechanisms of neurodevelopmental differences in psychiatric and neurological disorders. Previous sulcal pattern analysis used spectral graph matching of sulcal ...
Magnetic Resonance Imaging Image Interpretation, Computer-Assisted Cerebral Cortex Humans Deep Learning Heart Defects, Congenital Neural Networks, Computer Adolescent Female Child Male
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