AIMC Topic: Chemical and Drug Induced Liver Injury

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The prediction approach of drug-induced liver injury: response to the issues of reproducible science of artificial intelligence in real-world applications.

Briefings in bioinformatics Jul 18, 2022
In the previous study, we developed the generalized drug-induced liver injury (DILI) prediction model-ResNet18DNN to predict DILI based on multi-source combined DILI dataset and achieved better performance than that of previously published described ...
Humans Artificial Intelligence Chemical and Drug Induced Liver Injury
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Machine Learning from Omics Data.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2022
Machine learning (ML) already accelerates discoveries in many scientific fields and is the driver behind several new products. Recently, growing sample sizes enabled the use of ML approaches in larger omics studies. This work provides a guide through...
Support Vector Machine Chemical and Drug Induced Liver Injury Humans Machine Learning
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Editor's Highlight: Identification of Any Structure-Specific Hepatotoxic Potential of Different Pyrrolizidine Alkaloids Using Random Forests and Artificial Neural Networks.

Toxicological sciences : an official journal of the Society of Toxicology Dec 1, 2017
Pyrrolizidine alkaloids (PAs) are characteristic metabolites of some plant families and form a powerful defense mechanism against herbivores. More than 600 different PAs are known. PAs are ester alkaloids composed of a necine base and a necic acid, w...
Humans Neural Networks, Computer Machine Learning Pyrrolizidine Alkaloids Cyclic N-Oxides Heterocyclic Compounds, 2-Ring Liver Molecular Structure Dicarboxylic Acids Chemical and Drug Induced Liver Injury Quantitative Structure-Activity Relationship Reproducibility of Results Risk Assessment Algorithms Databases, Factual
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Antioxidant and hepatoprotective activities of Dicoma anomala Sond. aqueous root extract against carbon tetrachloride-induced liver damage in Wistar rats.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Aug 1, 2016
OBJECTIVE: To evaluates the antioxidant and hepatoprotective potentials of Dicoma anomala Sond. (Asteraceae) on body weight, feed and water intake, biochemical parameters and organ histology.
Drugs, Chinese Herbal Antioxidants Alanine Transaminase Rats, Wistar Protective Agents Plant Roots Superoxide Dismutase Carbon Tetrachloride Liver Chemical and Drug Induced Liver Injury Rats Aspartate Aminotransferases Animals Asteraceae Male Humans Female
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Protective effect of Yiguanjian decoction against DNA damage on concanavalin A-induced liver injury mice model.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Aug 1, 2016
OBJECTIVE: To investigate the inhibitory effect of Yiguanjian decoction (YD) on DNA damage in Concanavalin A (Con A)-induced liver injury mice model and to explain the possible mechanism.
Concanavalin A Humans Chemical and Drug Induced Liver Injury Alanine Transaminase Aspartate Aminotransferases Mice, Inbred BALB C Mice Liver Disease Models, Animal Drugs, Chinese Herbal Animals DNA Damage Male Protective Agents
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Probing the Hypothesis of SAR Continuity Restoration by the Removal of Activity Cliffs Generators in QSAR.

Current pharmaceutical design Jan 1, 2016
In this work we report the first attempt to study the effect of activity cliffs over the generalization ability of machine learning (ML) based QSAR classifiers, using as study case a previously reported diverse and noisy dataset focused on drug induc...
Machine Learning Algorithms Humans Quantitative Structure-Activity Relationship Chemical and Drug Induced Liver Injury
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Hepatoprotective Activity of Water Extracts from Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes) Against Tert-Butyl Hydroperoxide-Induced Oxidative Liver Injury in Primary Cultured Rat Hepatocytes.

International journal of medicinal mushrooms Jan 1, 2015
We examined the hepatoprotective activity of Inonotus obliquus water extract (IO-W) against tert-butyl hydroperoxide (t-BHP)-induced oxidative liver injury in the primary cultured rat hepatocyte. The 50% radical scavenging concentrations (SC50s) of I...
tert-Butylhydroperoxide Lipid Peroxidation Alanine Transaminase Basidiomycota Chemical and Drug Induced Liver Injury Glutathione Protective Agents Hepatocytes Malondialdehyde Rats, Sprague-Dawley Cells, Cultured Animals Plant Extracts Rats Oxidative Stress Humans
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