tert-Butylhydroperoxide

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Integration of transcriptomics, machine learning, and molecular simulations identifies key microvascular-protective genes VEGFA and BIRC3 mediated by tert-butylhydroquinone in diabetic kidney disease treatment.

European journal of pharmacology Oct 3, 2025
Diabetic kidney disease (DKD) is a microvascular complication of diabetes that can progress to renal failure. Tert-butylhydroquinone (TBHQ) exhibits renal protective effects in type II diabetes, but its regulatory role on microvascular protection-rel...
Gene Expression Regulation Endothelial Cells Microvessels Kidney Glomerulus Vascular Endothelial Growth Factor A Baculoviral IAP Repeat-Containing 3 Protein Gene Expression Profiling Hydroquinones Humans Transcriptome Gene Regulatory Networks tert-Butylhydroperoxide Machine Learning Diabetic Nephropathies
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Machine learning reveals genes impacting oxidative stress resistance across yeasts.

Nature communications Jul 1, 2025
Reactive oxygen species (ROS) are highly reactive molecules encountered by yeasts during routine metabolism and during interactions with other organisms, including host infection. Here, we characterize the variation in resistance to the ROS-inducing ...
Saccharomyces cerevisiae Gene Expression Regulation, Fungal Fungal Proteins Oxidoreductases Kluyveromyces Genes, Fungal tert-Butylhydroperoxide Machine Learning Oxidative Stress Reactive Oxygen Species Mannosyltransferases
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Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning.

Biochimica et biophysica acta Nov 13, 2014
Understanding the processes of mitochondrial dynamics (fission, fusion, biogenesis, and mitophagy) has been hampered by the lack of automated, deterministic methods to measure mitochondrial morphology from microscopic images. A method to quantify mit...
Cell Respiration tert-Butylhydroperoxide Carbonyl Cyanide m-Chlorophenyl Hydrazone Electron Transport Phenotype Animals Imaging, Three-Dimensional Mice Artificial Intelligence Mitochondria Stress, Physiological Membrane Potential, Mitochondrial Sodium-Potassium-Exchanging ATPase Oxidants Cell Membrane Cell Line Cell Survival
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Hepatoprotective Activity of Water Extracts from Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes) Against Tert-Butyl Hydroperoxide-Induced Oxidative Liver Injury in Primary Cultured Rat Hepatocytes.

International journal of medicinal mushrooms Jan 1, 2015
We examined the hepatoprotective activity of Inonotus obliquus water extract (IO-W) against tert-butyl hydroperoxide (t-BHP)-induced oxidative liver injury in the primary cultured rat hepatocyte. The 50% radical scavenging concentrations (SC50s) of I...
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tert-Butylhydroperoxide Chemical and Drug Induced Liver Injury Oxidative Stress Cells, Cultured Protective Agents Plant Extracts Animals Humans Hepatocytes Rats Glutathione Lipid Peroxidation Rats, Sprague-Dawley Malondialdehyde Basidiomycota Alanine Transaminase
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