AIMC Topic: Clinical Trials as Topic
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Nasal Dilators (Breathe Right Strips and NoZovent) for Snoring and OSA: A Systematic Review and Meta-Analysis.
Pulmonary medicine
Dec 13, 2016
. To systematically review the international literature for studies evaluating internal (NoZovent) and external (Breathe Right Strips) nasal dilators as treatment for obstructive sleep apnea (OSA). . Systematic review with meta-analysis. . Four datab...
Learning disease relationships from clinical drug trials.
Journal of the American Medical Informatics Association : JAMIA
May 17, 2016
OBJECTIVE: Our objective is to test the limits of the assumption that better learning from data in medicine requires more granular data. We hypothesize that clinical trial metadata contains latent scientific, clinical, and regulatory expert knowledge...
Will they participate? Predicting patients' response to clinical trial invitations in a pediatric emergency department.
Journal of the American Medical Informatics Association : JAMIA
Apr 27, 2016
OBJECTIVE: (1) To develop an automated algorithm to predict a patient's response (ie, if the patient agrees or declines) before he/she is approached for a clinical trial invitation; (2) to assess the algorithm performance and the predictors on real-w...
Bilateral robots for upper-limb stroke rehabilitation: State of the art and future prospects.
Medical engineering & physics
Apr 24, 2016
Robot-assisted bilateral upper-limb training grows abundantly for stroke rehabilitation in recent years and an increasing number of devices and robots have been developed. This paper aims to provide a systematic overview and evaluation of existing bi...
Automated identification of molecular effects of drugs (AIMED).
Journal of the American Medical Informatics Association : JAMIA
Apr 23, 2016
INTRODUCTION: Genomic profiling information is frequently available to oncologists, enabling targeted cancer therapy. Because clinically relevant information is rapidly emerging in the literature and elsewhere, there is a need for informatics technol...
Extracting genetic alteration information for personalized cancer therapy from ClinicalTrials.gov.
Journal of the American Medical Informatics Association : JAMIA
Mar 24, 2016
OBJECTIVE: Clinical trials investigating drugs that target specific genetic alterations in tumors are important for promoting personalized cancer therapy. The goal of this project is to create a knowledge base of cancer treatment trials with annotati...
canSAR: an updated cancer research and drug discovery knowledgebase.
Nucleic acids research
Dec 15, 2015
canSAR (http://cansar.icr.ac.uk) is a publicly available, multidisciplinary, cancer-focused knowledgebase developed to support cancer translational research and drug discovery. canSAR integrates genomic, protein, pharmacological, drug and chemical da...
Textual inference for eligibility criteria resolution in clinical trials.
Journal of biomedical informatics
Sep 14, 2015
Clinical trials are essential for determining whether new interventions are effective. In order to determine the eligibility of patients to enroll into these trials, clinical trial coordinators often perform a manual review of clinical notes in the e...
RobotReviewer: evaluation of a system for automatically assessing bias in clinical trials.
Journal of the American Medical Informatics Association : JAMIA
Jun 22, 2015
OBJECTIVE: To develop and evaluate RobotReviewer, a machine learning (ML) system that automatically assesses bias in clinical trials. From a (PDF-formatted) trial report, the system should determine risks of bias for the domains defined by the Cochra...
Increasing the efficiency of trial-patient matching: automated clinical trial eligibility pre-screening for pediatric oncology patients.
BMC medical informatics and decision making
Apr 14, 2015
BACKGROUND: Manual eligibility screening (ES) for a clinical trial typically requires a labor-intensive review of patient records that utilizes many resources. Leveraging state-of-the-art natural language processing (NLP) and information extraction (...
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