BACKGROUND AND OBJECTIVES: The choroid plexus (ChP) plays a crucial role in maintaining brain health. Alzheimer disease (AD) pathologies may damage the ChP and accelerate neurodegeneration. Previous imaging studies have found overall increased ChP vo...
BACKGROUND: Parkinson's disease is a movement disorder featuring motor symptoms and cognitive decline, which can manifest as mild cognitive impairment. The incidence of mild cognitive impairment increases with disease progression, and Parkinson's dis...
Metabolomics : Official journal of the Metabolomic Society
Nov 15, 2025
INTRODUCTION: Dementia can be prevented through early intervention; hence, there is an urgent need for biomarkers to help diagnose mild cognitive impairment (MCI).
This study investigated the effect of hemodynamic data during cardiopulmonary bypass (CPB) on neurocognitive impairment in patients undergoing coronary artery bypass graft (CABG) surgery using machine learning algorithms. Twenty-eight CABG patients w...
BACKGROUND: Mild cognitive impairment (MCI) represents a transitional stage to Alzheimer's disease (AD), making progression prediction crucial for timely intervention. Predictive models integrating clinical, laboratory, and survival data can enhance ...
BACKGROUND: Cytosine modifications play critical roles in gene regulation and disease pathogenesis. Elucidating novel epigenetic contributions to Alzheimer's disease (AD) could advance diagnostic, prognostic, and therapeutic strategies. 5-hydroxymeth...
BACKGROUND: The worldwide rise in dementia creates an urgent need for screening methods that are both sensitive and easy to administer. Dual-task walking-requiring people to walk while performing a second cognitive or motor task-meets these criteria ...
OBJECTIVE: Mild cognitive impairment (MCI) signals cognitive decline beyond normal aging and increases dementia risk. Early identification enables preventative interventions, yet many patients in primary care go undetected. This study examines whethe...
Alzheimer's disease (AD), the most prevalent neurodegenerative disorder, is marked by the accumulation of amyloid-β (Aβ) plaques. Although cerebral Aβ positron emission tomography (Aβ-PET) remains the gold standard for assessing cerebral Aβ burden, i...
Journal of neuroengineering and rehabilitation
Oct 22, 2025
BACKGROUND: Electroencephalogram (EEG) microstates provide insights into large-scale brain network coordination, revealing distinct neural dynamics within specific frequency bands associated with cognitive processes and neurological disorders. Critic...
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