AIMC Topic: Cognitive Dysfunction

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Machine learning for predicting cognitive decline within five years in Parkinson's disease: Comparing cognitive assessment scales with DAT SPECT and clinical biomarkers.

PloS one
OBJECTIVE: Parkinson's disease (PD) is an age-related neurodegenerative condition characterized mostly by motor symptoms. Although a wide range of non-motor symptoms (NMS) are frequently experienced by PD patients. One of the important and common NMS...

AI-based differential diagnosis of dementia etiologies on multimodal data.

Nature medicine
Differential diagnosis of dementia remains a challenge in neurology due to symptom overlap across etiologies, yet it is crucial for formulating early, personalized management strategies. Here, we present an artificial intelligence (AI) model that har...

Predicting changes in brain metabolism and progression from mild cognitive impairment to dementia using multitask Deep Learning models and explainable AI.

NeuroImage
BACKGROUND: The prediction of Alzheimer's disease (AD) progression from its early stages is a research priority. In this context, the use of Artificial Intelligence (AI) in AD has experienced a notable surge in recent years. However, existing investi...

Prediction of Alzheimer's disease progression within 6 years using speech: A novel approach leveraging language models.

Alzheimer's & dementia : the journal of the Alzheimer's Association
INTRODUCTION: Identification of individuals with mild cognitive impairment (MCI) who are at risk of developing Alzheimer's disease (AD) is crucial for early intervention and selection of clinical trials.

Siamese Graph Convolutional Network quantifies increasing structure-function discrepancy over the cognitive decline continuum.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Alzheimer's disease dementia (ADD) is well known to induce alterations in both structural and functional brain connectivity. However, reported changes in connectivity are mostly limited to global/local network features, whic...

A deep learning model for generating [F]FDG PET Images from early-phase [F]Florbetapir and [F]Flutemetamol PET images.

European journal of nuclear medicine and molecular imaging
INTRODUCTION: Amyloid-β (Aβ) plaques is a significant hallmark of Alzheimer's disease (AD), detectable via amyloid-PET imaging. The Fluorine-18-Fluorodeoxyglucose ([F]FDG) PET scan tracks cerebral glucose metabolism, correlated with synaptic dysfunct...

A multimodal machine learning model for predicting dementia conversion in Alzheimer's disease.

Scientific reports
Alzheimer's disease (AD) accounts for 60-70% of the population with dementia. Mild cognitive impairment (MCI) is a diagnostic entity defined as an intermediate stage between subjective cognitive decline and dementia, and about 10-15% of people annual...

Intelligent prediction of Alzheimer's disease via improved multifeature squeeze-and-excitation-dilated residual network.

Scientific reports
This study aimed to address the issue of larger prediction errors existing in intelligent predictive tasks related to Alzheimer's disease (AD). A cohort of 487 enrolled participants was categorized into three groups: normal control (138 individuals),...

Detecting Alzheimer's Disease Stages and Frontotemporal Dementia in Time Courses of Resting-State fMRI Data Using a Machine Learning Approach.

Journal of imaging informatics in medicine
Early, accurate diagnosis of neurodegenerative dementia subtypes such as Alzheimer's disease (AD) and frontotemporal dementia (FTD) is crucial for the effectiveness of their treatments. However, distinguishing these conditions becomes challenging whe...