OBJECTIVES: Patient classification into specific molecular subtypes is paramount in biomedical research and clinical practice to face complex, heterogeneous diseases. Existing methods, especially for gene expression-based cancer subtyping, often simp...
The very early days of artificial intelligence (AI) in healthcare are behind us. AI is now spreading in the healthcare sector and is gradually being implemented in routine clinical practice. Driven by the increasing digitization of microscope slides,...
The digenic inheritance hypothesis holds the potential to enhance diagnostic yield in rare diseases. Computational approaches capable of accurately interpreting and prioritizing digenic combinations of variants based on the proband's phenotypes and f...
Interdisciplinary sciences, computational life sciences
Jun 1, 2025
circRNAs are a type of single-stranded non-coding RNA molecules, and their unique feature is their closed circular structure. The interaction between circRNAs and RNA-binding proteins (RBPs) plays a key role in biological functions and is crucial for...
IEEE journal of biomedical and health informatics
Jun 1, 2025
Gene selection and cancer classification are inherently multi-objective tasks that require balancing competing objectives, such as maximizing classification accuracy while minimizing irrelevant or redundant genes. Existing methods often optimize a si...
IEEE journal of biomedical and health informatics
Jun 1, 2025
Disease is one of the primary factors affecting life activities, with complex etiologies often influenced by gene expression and mutation. Currently, wet lab experiments have analyzed the mechanisms of mutations, but these are usually limited by the ...
IEEE journal of biomedical and health informatics
Jun 1, 2025
With the rapid development of Large Language Model (LLM) technology, it has become an indispensable force in biomedical data analysis research. However, biomedical researchers currently have limited knowledge about LLM. Therefore, there is an urgent ...
IEEE journal of biomedical and health informatics
Jun 1, 2025
Single-cell multi-omics sequencing technology comprehensively considers various molecular features to reveal the complexity of cells information. The clustering analysis of multi-omics data provides new insight into cellular heterogeneity. However, m...
IEEE journal of biomedical and health informatics
Jun 1, 2025
Non-coding RNAs (ncRNAs), which do not encode proteins, have been implicated in chemotherapy resistance in cancer treatment. Given the high costs and time requirements of traditional biological experiments, there is an increasing need for computation...
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