Mitochondria play a crucial role in cellular respiration and immune responses. Mitochondrial DNA (mtDNA) haplogroups and variants have been associated with various diseases, including COVID-19. This study analyzed complete mtDNA sequences from 467 Br...
The emergence of online education, e.g., intelligent tutoring system (ITS), complements or partially replaces conventional offline education, especially during the COVID-19 pandemic. Knowledge tracing (KT) plays a pivotal role in the intelligent tuto...
The universal demand for the development and deployment of responsive medical infrastructure and damage control techniques, including the application of technology, is the foremost necessity that emerged immediately in the post-pandemic era. Numerous...
Questions remain about how best to focus surveillance efforts for COVID-19 and other emerging respiratory diseases. We used an archive of COVID-19 data in Colorado from October 2020 to March 2024 to reconstruct seven real-time surveillance indicators...
The advancement of clinical natural language processing systems is crucial to exploit the wealth of textual data contained in medical records. Diverse data sources are required in different languages and from different sites to represent global healt...
Understanding SARS-CoV-2 human protein-protein interactions (PPIs) and the host response to infection is essential for developing effective COVID-19 antivirals. However, how the ancestral virus and its variants remodel virus-host protein assemblies i...
Deep learning models require large amounts of annotated data, which are hard to obtain in the medical field, as the annotation process is laborious and depends on expert knowledge. This data scarcity hinders a model's ability to generalise effectivel...
Biochemical and biophysical research communications
Jun 28, 2025
SARS-CoV-2 infection is highly contagious, prompting the World Health Organization to classify it as a global public health emergency. The virus has numerous potential hosts, which complicates efforts for effective prevention, diagnosis, and treatmen...
The papain-like protease (PLpro), a cysteine protease found in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), plays a crucial role in viral replication by cleaving the viral polyproteins and interfering with the host's innate immune re...
Health policy (Amsterdam, Netherlands)
Jun 26, 2025
The SARS-COV2 pandemic has highlighted the urgent need for agile and responsive disease surveillance systems. To strengthen epidemiological surveillance and improve pandemic preparedness, policymakers must adopt real-time signal detection tools that ...
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