Depression and anxiety are highly prevalent among patients with breast cancer. We tested the capacity of personal resources (psychological resilience, social support, and process of recovery) for predicting depression, anxiety, and comorbid depressio...
The digital transformation of healthcare is revolutionizing the management of medical institutions, improving operational efficiency, patient outcomes, and data security. With the increasing complexity of healthcare systems, the integration of cuttin...
Since the promulgation of the July 21, 2009 law on hospital reform and patients, health and territories, known as the HPST law, therapeutic patient education (TPE) and telemedicine have become key pillars in the modernization of the healthcare system...
BACKGROUND: The COVID-19 pandemic intensified the challenges associated with mental health and substance use (SU), with societal and economic upheavals leading to heightened stress and increased reliance on drugs as a coping mechanism. Centers for Di...
International journal of molecular sciences
40244295
This study explores the role of intrinsically disordered regions (IDRs) in the SARS-CoV-2 proteome and their potential as targets for small-molecule drug discovery. Experimentally validated intrinsic disordered regions from the literature were utiliz...
BACKGROUND: Methods that enable early outbreak detection represent powerful tools in epidemiological surveillance, allowing adequate planning and timely response to disease surges. Syndromic surveillance data collected from primary healthcare encount...
Bioactivity optimization is a crucial and technical task in the early stages of drug discovery, traditionally carried out through iterative substituent optimization, a process that is often both time-consuming and expensive. To address this challenge...
BACKGROUND: Several studies explored factors related to adverse clinical outcomes among COVID-19 patients but lacked analysis of the impact of the temporal data shifts on the strength of association between different predictors and adverse outcomes. ...
Optical spectroscopy, a noninvasive molecular sensing technique, offers valuable insights into material characterization, molecule identification, and biosample analysis. Despite the informativeness of high-dimensional optical spectra, their interpre...
BACKGROUND: Remdesivir (RDV) was the first antiviral approved for mild-to-moderate COVID-19 and for those patients at risk for progression to severe disease after clinical trials supported its association with improved outcomes. Real-world evidence (...