Computational prediction of binding between neoantigen peptides and major histocompatibility complex (MHC) proteins can be used to predict patient response to cancer immunotherapy. Current neoantigen predictors focus on estimation of MHC binding aff...
BACKGROUND: Use of medication can cause adverse drug reactions (ADRs), unwanted or unexpected events, which are a major safety concern. Drug labels, or prescribing information or package inserts, describe ADRs. Therefore, systematically identifying A...
BMC medical informatics and decision making
Dec 23, 2019
BACKGROUND: Text mining and natural language processing of clinical text, such as notes from electronic health records, requires specific consideration of the specialized characteristics of these texts. Deep learning methods could potentially mitigat...
BMC medical informatics and decision making
Dec 21, 2019
BACKGROUND: Supervised machine learning algorithms have been a dominant method in the data mining field. Disease prediction using health data has recently shown a potential application area for these methods. This study ai7ms to identify the key tren...
Statistical data-mining (DM) and machine learning (ML) are promising tools to assist in the analysis of complex dataset. In recent decades, in the precision of agricultural development, plant phenomics study is crucial for high-throughput phenotyping...
Computational intelligence and neuroscience
Dec 19, 2019
Aspect-level sentiment classification aims to identify the sentiment polarity of a review expressed toward a target. In recent years, neural network-based methods have achieved success in aspect-level sentiment classification, and these methods fall ...
BACKGROUND: In the hospital setting, it is crucial to identify patients at risk for deterioration before it fully develops, so providers can respond rapidly to reverse the deterioration. Rapid response (RR) activation criteria include a subjective co...
In this study we propose the use of text mining and machine learning methods to predict and detect Surgical Site Infections (SSIs) using textual descriptions of surgeries and post-operative patients' records, mined from the database of a high complex...
Journal of chemical information and modeling
Dec 12, 2019
A proliferation of data sources has led to the notional existence of an implicit Knowledge Graph (KG) that contains vast amounts of biological knowledge contributed by distributed Application Programming Interfaces (APIs). However, challenges arise w...
BACKGROUND: Disease comorbidity is popular and has significant indications for disease progress and management. We aim to detect the general disease comorbidity patterns in Chinese populations using a large-scale clinical data set.
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