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LightGBM: An Effective and Scalable Algorithm for Prediction of Chemical Toxicity-Application to the Tox21 and Mutagenicity Data Sets.

Journal of chemical information and modeling
Machine learning algorithms have attained widespread use in assessing the potential toxicities of pharmaceuticals and industrial chemicals because of their faster speed and lower cost compared to experimental bioassays. Gradient boosting is an effect...

REFUGE Challenge: A unified framework for evaluating automated methods for glaucoma assessment from fundus photographs.

Medical image analysis
Glaucoma is one of the leading causes of irreversible but preventable blindness in working age populations. Color fundus photography (CFP) is the most cost-effective imaging modality to screen for retinal disorders. However, its application to glauco...

Uncovering Thousands of New Peptides with Sequence-Mask-Search Hybrid Peptide Sequencing Framework.

Molecular & cellular proteomics : MCP
Typical analyses of mass spectrometry data only identify amino acid sequences that exist in reference databases. This restricts the possibility of discovering new peptides such as those that contain uncharacterized mutations or originate from unexpec...

Fully automated 3D segmentation and separation of multiple cervical vertebrae in CT images using a 2D convolutional neural network.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: We investigated a novel method using a 2D convolutional neural network (CNN) to identify superior and inferior vertebrae in a single slice of CT images, and a post-processing for 3D segmentation and separation of cervical ve...

IDRiD: Diabetic Retinopathy - Segmentation and Grading Challenge.

Medical image analysis
Diabetic Retinopathy (DR) is the most common cause of avoidable vision loss, predominantly affecting the working-age population across the globe. Screening for DR, coupled with timely consultation and treatment, is a globally trusted policy to avoid ...

Applying density-based outlier identifications using multiple datasets for validation of stroke clinical outcomes.

International journal of medical informatics
INTRODUCTION: Clinicians commonly use the modified Rankin Scale (mRS) and the Barthel Index (BI) to measure clinical outcome after stroke. These are potential targets in machine learning models for stroke outcome prediction. Therefore, the quality of...

Simulation of hyperelastic materials in real-time using deep learning.

Medical image analysis
The finite element method (FEM) is among the most commonly used numerical methods for solving engineering problems. Due to its computational cost, various ideas have been introduced to reduce computation times, such as domain decomposition, parallel ...

CNN-based diagnosis models for canine ulcerative keratitis.

Scientific reports
The purpose of this methodological study was to develop a convolutional neural network (CNN), which is a recently developed deep-learning-based image recognition method, to determine corneal ulcer severity in dogs. The CNN model was trained with imag...

Machine-based detection and classification for bone marrow aspirate differential counts: initial development focusing on nonneoplastic cells.

Laboratory investigation; a journal of technical methods and pathology
Bone marrow aspirate (BMA) differential cell counts (DCCs) are critical for the classification of hematologic disorders. While manual counts are considered the gold standard, they are labor intensive, time consuming, and subject to bias. A reliable a...

Application of fast curvelet Tsallis entropy and kernel random vector functional link network for automated detection of multiclass brain abnormalities.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Binary classification of brain magnetic resonance (MR) images has made remarkable progress and many automated systems have been developed in the last decade. Multiclass classification of brain MR images is comparatively more challenging and has great...