PLoS computational biology
Feb 10, 2025
There is an important challenge in systematically interpreting the internal representations of deep neural networks (DNNs). Existing techniques are often less effective for non-tabular tasks, or they primarily focus on qualitative, ad-hoc interpretat...
IEEE journal of biomedical and health informatics
Feb 10, 2025
Obstructive sleep apnea (OSA) in children is a prevalent and serious respiratory condition linked to cardiovascular morbidity. Polysomnography, the standard diagnostic approach, faces challenges in accessibility and complexity, leading to underdiagno...
IEEE journal of biomedical and health informatics
Feb 10, 2025
High-performance prediction of prostate cancer metastasis based on single nucleotide variations remains a challenge. Therefore, we developed a novel biologically informed deep learning framework, named M-NET, for the prediction of prostate cancer met...
IEEE journal of biomedical and health informatics
Feb 10, 2025
The medical community has grappled with the challenge of analysis and early detection of severe and unknown adverse drug reactions (ADRs) from Spontaneous Reporting Systems (SRSs) like the FDA Adverse Event Reporting System (FAERS), which often lack ...
IEEE journal of biomedical and health informatics
Feb 10, 2025
The rapid integration of deep learning-powered artificial intelligence systems in diverse applications such as healthcare, credit assessment, employment, and criminal justice has raised concerns about their fairness, particularly in how they handle v...
IEEE journal of biomedical and health informatics
Feb 10, 2025
The subcellular localization of circular RNAs (circRNAs) is crucial for understanding their functional relevance and regulatory mechanisms. CircRNA subcellular localization exhibits variations across different cell lines, demonstrating the diversity ...
IEEE journal of biomedical and health informatics
Feb 10, 2025
Predicting the unprecedented, nonlinear nature of COVID-19 presents a significant public health challenge. Recent advances in deep learning, such as graph neural networks (GNNs), recurrent neural networks (RNNs), and Transformers, have enhanced predi...
IEEE journal of biomedical and health informatics
Feb 10, 2025
Sleep is a fundamental human activity, and automated sleep staging holds considerable investigational potential. Despite numerous deep learning methods proposed for sleep staging that exhibit notable performance, several challenges remain unresolved,...
IEEE journal of biomedical and health informatics
Feb 10, 2025
Diffusion magnetic resonance imaging (dMRI) is a non-invasive method for capturing the microanatomical information of tissues by measuring the diffusion weighted signals along multiple directions, which is widely used in the quantification of microst...
IEEE journal of biomedical and health informatics
Feb 10, 2025
Tumor heterogeneity presents a significant challenge in predicting drug responses, especially as missense mutations within the same gene can lead to varied outcomes such as drug resistance, enhanced sensitivity, or therapeutic ineffectiveness. These ...