BACKGROUND: Although chest X-rays (CXRs) are widely used, diagnosing mitral stenosis (MS) based solely on CXR findings remains challenging in some cases.
Proceedings of the National Academy of Sciences of the United States of America
Dec 24, 2025
Understanding protein structure and dynamics is crucial for basic biology and drug design. Conventional methods often provide static conformations that inadequately capture protein flexibility. We present PackDock, a framework that integrates deep le...
By eliminating the need to alter the source images, this paper introduces a secure technique for coverless image steganography that strengthens defense against steganalysis attacks. Our method makes use of a hybrid Generative Adversarial Network (GAN...
Journal of chemical information and modeling
Dec 23, 2025
Accurate protein subcellular localization (PSL) is essential for proteins to perform their biological functions, whereas protein mis-localization can disrupt cellular processes and contribute to various diseases, particularly cancer. Although spatial...
Journal of chemical information and modeling
Dec 23, 2025
Target-specific scoring functions offer a promising route to improve structure-based virtual screening beyond generic, bias-prone scoring schemes. Here, we introduce AttentionScore, a deep learning-based scoring function for METTL3 that integrates li...
BACKGROUND: Impacted canines are one of the most frequently encountered dental anomalies in maxillofacial practice. Accurate localization of these teeth is crucial for treatment planning, and Cone Beam Computed Tomography (CBCT) offers detailed 3D im...
BACKGROUND: The development of spatial transcriptomics (ST) has enabled biologists to measure transcriptome data on an entire tissue and retain spatial information. It gives us the opportunity to fully understand the tissue microenvironment and ident...
Micro-computed tomography (μCT) provides 3D images of congenital heart defects (CHD) in mice. However, diagnosing CHD from μCT scans is time-consuming and requires clinical expertise. Here, we present a deep learning approach to automatically segment...
Deep Learning (DL) and Machine Learning (ML) algorithms are adept at managing and classifying a wide range of data formats, including time series, text, and images, addressing challenges in both supervised and unsupervised learning. However, the prac...
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
Dec 23, 2025
Cis-regulatory elements (CREs) govern gene expression, and the relationship between non-coding regulatory elements and gene expression is inherently complex. To further elucidate how these elements influence gene expression, we refined previous model...
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